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Critical Reviews™ in Eukaryotic Gene Expression

Impact-Faktor: 1.660
5-jähriger Impact-Faktor: 3.082

ISSN Druckformat: 1045-4403
ISSN Online: 2162-6502

Volumen 27, 2017

Volumen 26, 2016

Volumen 25, 2015

Volumen 24, 2014

Volumen 23, 2013

Volumen 22, 2012

Volumen 21, 2011

Volumen 20, 2010

Volumen 19, 2009

Volumen 18, 2008

Volumen 17, 2007

Volumen 16, 2006

Volumen 15, 2005

Volumen 14, 2004

Volumen 13, 2003

Volumen 12, 2002

Volumen 11, 2001

Volumen 10, 2000

Volumen 9, 1999

Volumen 8, 1998

Volumen 7, 1997

Volumen 6, 1996

Volumen 5, 1995

Volumen 4, 1994

Ausgabe 1

Ausgabe 2-3

Critical Reviews™ in Eukaryotic Gene Expression

Executive Editors: Gary Stein , Janet L. Stein , Jane B. Lian

Managing Editor: Taryn Gehman

Ziele und Zweck

Critical ReviewsTM in Eukaryotic Gene Expression presents timely concepts and experimental approaches that are contributing to rapid advances in our mechanistic understanding of gene regulation, organization, and structure within the contexts of biological control and the diagnosis/treatment of disease. The journal provides in-depth critical reviews, on well-defined topics of immediate interest, written by recognized specialists in the field. Extensive literature citations provide a comprehensive information resource.
Reviews are developed from an historical perspective and suggest directions that can be anticipated. Strengths as well as limitations of methodologies and experimental strategies are considered. The contributions of molecular, cellular, biochemical, genetic, genomic, and proteomic approaches to eukaryotic gene expression are incorporated into reviews. The relationship between gene structure and function is stressed, with emphasis on coordinate control of biological processes. Regulatory mechanisms are explored from the perspective of sequences and regulatory molecules that influence structure and expression of eukaryotic genes as well as in relation to cellular architecture and its relationship to development of cell specialization and tissue organization. Processes that include genetic and epigenetic control, cell cycle regulation, differentiation, transformation and tumorigenesis, senescence, cell survival and apoptosis, development, reproduction, cell fate, lineage commitment, stem cell biology and regenerative medicine are covered.
All articles are by invitation; however, the editors welcome suggestions of both topics and authors.

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Bone Modeling and Remodeling
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Lysine-specific histone demethylase 1 (LSD1): A potential molecular target for tumor therapy
Yingwei Chen , Wen Jie, Weihui Yan, Kejun Zhou, Yongtao Xiao

Dual Role of p21 in the Progression of Cancer and Its Treatment
Amna Parveen, Muhammad Sajid Hamid Akash, Kanwal Rehman, Whang Wan Kyunn

Review of Poly (ADP-ribose) Polymerase (PARP) Mechanisms of Action and Rationale for Targeting in Cancer and Other Diseases
Julio Morales, Longshan Li, Farjana J. Fattah, Ying Dong, Erik A. Bey, Malina Patel, Jinming Gao, David A. Boothman