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Hemodynamic Basis of Atherosclerosis

ISBN:
978-1-56700-029-0 (Imprimir)
978-1-56700-436-6 (En Línea)

Hemodynamic Basis of Atherosclerosis

Descripción

In this new edition of his book the author continues to give ample evidence that heart disease can be better understood if the fluid dynamics and hydraulics of the body blood systems are considered, rather than looking to cholesterol levels, diets, or drugs as influencing factors in the development of atherosclerosis. Illustrated with over 100 color plates, figures and diagrams.



105 pages, © 1995

Tabla de Contenidos:

Foreword to the Second Edition
Preface to the Second Edition
Acknowledgments to the Second Edition
Foreword to the First Edition
Preface to the First Edition
Acknowledgments to the First Edition
1 Introduction
2 Fluid Mechanics: Hemodynamics and Vascular Dynamics
3 Relevant Hydraulic Parameters
4 Sites of Predilection or Localization and the Mechanism for Inception and Progressive Changes
5 Blood Flow Characteristics in Arteries
Laminar Flow
Pulsatile How
Blood Viscosity
Movement of the Arterial Wall (Elasticity)
Pressure-Flow Relations
Cavitation
Boundary Layer
Stresses Generated by Flowing Blood
Shear Stress
Turbulence
Divider Flow
Suction Effect
6 Theoretical Calculations for Different Flow Patterns
Taper
Curvature, Bends, and the Force Equation
Relation between Pressure and Radius of Curvature
Calculations
Attachment
Branching
Ostial Lesions
Bifurcation
Bifurcation of the Aorta and Common Iliac Arteries
Computational Simulation of Bifurcation How
Results and Discussion
Summary and Conclusion
Trifurcation
Linear Lesion
Other Considerations
7 Human Atherosclerosis
Vascular Embryology and Subsequent Development (The Reparative Response)
Illustrative Examples
The Coronary Circulation
The Aorta
Bifurcation of the Aorta and Common Iliac Arteries
Splenic Arteries
Ostial or Branch Lesions
Comment
Summary
Arteriovenous Fistulas
Pulmonary Artery
Veins
Ductus Arteriosus
8 Experimental Atherosclerosis in Dogs
Aim of Experiments
Method
Findings
Gross Observations
Microscopic Observations
Discussion
9 Hydraulic Model Findings
10 Discussion and Conclusions
Blood Flow—A Life Requirement
Stimulus vs. Response
The Reparative Response
Cure vs. Control or Modification
Characteristics of Blood Flow in Arteries That Influence the Development of Atherosclerosis
Regression
Restenosis
Hypertension
Exercise
The Cholesterol-Heart Disease Controversy
The Cholesterol-Heart Disease Hypothesis (Critique)—Time to Change Course?
Summary
References
INDEX