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Critical Reviews™ in Eukaryotic Gene Expression

Facteur d'impact: 1.660
Facteur d'impact sur 5 ans: 3.082

ISSN Imprimer: 1045-4403
ISSN En ligne: 2162-6502

Critical Reviews™ in Eukaryotic Gene Expression

Executive Editors: Gary Stein , Janet L. Stein , Jane B. Lian

Managing Editor: Taryn Gehman

Objectifs et champs d'application

Critical ReviewsTM in Eukaryotic Gene Expression presents timely concepts and experimental approaches that are contributing to rapid advances in our mechanistic understanding of gene regulation, organization, and structure within the contexts of biological control and the diagnosis/treatment of disease. The journal provides in-depth critical reviews, on well-defined topics of immediate interest, written by recognized specialists in the field. Extensive literature citations provide a comprehensive information resource.
Reviews are developed from an historical perspective and suggest directions that can be anticipated. Strengths as well as limitations of methodologies and experimental strategies are considered. The contributions of molecular, cellular, biochemical, genetic, genomic, and proteomic approaches to eukaryotic gene expression are incorporated into reviews. The relationship between gene structure and function is stressed, with emphasis on coordinate control of biological processes. Regulatory mechanisms are explored from the perspective of sequences and regulatory molecules that influence structure and expression of eukaryotic genes as well as in relation to cellular architecture and its relationship to development of cell specialization and tissue organization. Processes that include genetic and epigenetic control, cell cycle regulation, differentiation, transformation and tumorigenesis, senescence, cell survival and apoptosis, development, reproduction, cell fate, lineage commitment, stem cell biology and regenerative medicine are covered.
All articles are by invitation; however, the editors welcome suggestions of both topics and authors.

La plupart des articles téléchargés

Macrophage Polarization: Implications on Metabolic Diseases and the Role of Exercise
Loreana Sanches Silveira, Barbara de Moura Mello Antunes, Andre Luis Araujo Minari, Ronaldo Vagner Thomatieli dos Santos, José Cesar Rosa Neto, Fábio Santos Lira

Bone Modeling and Remodeling
Ego Seeman

mTOR, AMPK, and Sirt1: Key Players in Metabolic Stress Management
Silvia Cetrullo, Stefania D'Adamo, Benedetta Tantini, Rosa Maria Borzi , Flavio Flamigni

Lysine-specific histone demethylase 1 (LSD1): A potential molecular target for tumor therapy
Yingwei Chen , Wen Jie, Weihui Yan, Kejun Zhou, Yongtao Xiao

Dual Role of p21 in the Progression of Cancer and Its Treatment
Amna Parveen, Muhammad Sajid Hamid Akash, Kanwal Rehman, Whang Wan Kyunn

Review of Poly (ADP-ribose) Polymerase (PARP) Mechanisms of Action and Rationale for Targeting in Cancer and Other Diseases
Julio Morales, Longshan Li, Farjana J. Fattah, Ying Dong, Erik A. Bey, Malina Patel, Jinming Gao, David A. Boothman