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Journal of Environmental Pathology, Toxicology and Oncology

ISSN for PRINT: 0731-8898

Institutional price:	$672.00
Issues per year:	4

Best Paper Award Selection - Editorial Board Site

2001, Volume20

79 pages

Issue price - $160.00

Expression of p53 and Lactate Dehydrogenase in Murine Fibrosarcoma Following Exposure to g-Radiation

Khalida Wani
Radiation Oncology Division, Nanavathi Hospital and Medical Research Centre, Mumbai, India

Rema Rajagopalan
Radiation Biology Division, Bhabha Atomic Research Centre, Bombay, India

Nagaraj G. Huilgol
Radiation Oncology Division, Nanavathi Hospital and Medical Research Centre, Mumbai, India

Cherupally Krishnan K. Nair
Radiation Biology and Health Sciences Division, Bhabha Atomic Research Centre, Bombay, India

ABSTRACT

Radiation-induced alterations in the levels of p53 and lactate dehydrogenase activities were studied in fibrosarcoma, following exposure to different doses of g-irradiation (2–10 Gy). The levels of p53 were elevated in the cytoplasm, while the lactate dehydrogenase activity in tumor tissue was considerably decreased.