Journal of Environmental Pathology, Toxicology and Oncology

ISSN for PRINT: 0731-8898

For Online Access

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2002, Volume21

Issue 3

77 pages

Issue price - $160.00

Jasbir Singh
Department of Biochemistry, Panjab University, Chandigarh, India

Kovleen
Department of Biochemistry, Panjab University, Chandigarh, India

Harinder M. Dani
Department of Biochemistry, Panjab University, Chandigarh, 160014, India

Rajeshwar Sharma
Department of Biochemistry/Chemistry, Panjab University, Chandigarh-160014, India

Chemical carcinogens are organ selective and not organ specific. Microsomal degranulation elution profiles employing sepharose CL-2B gel filtration for the separation of microsomes from different organs of rats before and after treatment with some known chemical carcinogens have shown for the first time that carcinogens selectively detach maximum ribosomes from rough reticular membranes of their target organs. The detachment of ribosomes from other organs varies, but is comparatively lesser than that in the target organs. A chemical carcinogen might, therefore, be tumorigenic for several organs, possibly depending on the dose reaching a particular organ and its activation to the ultimate form of the carcinogen.

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