Journal of Environmental Pathology, Toxicology and Oncology

ISSN for PRINT: 0731-8898

For Online Access

Best Paper Award Selection - Editorial Board Site

2005, Volume24

Issue 2

76 pages

DOI: 10.1615/JEnvPathToxOncol.v24.i2

Issue price - $160.00

Ajanta Halder
Department of Genetics, Vivekananda Institute of Medical Sciences, Ramakrishna Mission Seva Pratisthan, Kolkata, India

Ranjan Raychowdhury
Department of ENT Surgery, Vivekananda Institute of Medical Sciences, Ramakrishna Mission Seva Pratisthan, Kolkata, India

Asish Ghosh
Department of Facial and Maxillary Surgery, Vivekananda Institute of Medical Sciences, Ramakrishna Mission Seva Pratisthan, Kolkata, India

Madhusnata De
Department of Genetics, Vivekananda Institute of Medical Sciences, Ramakrishna Mission Seva Pratisthan, Kolkata, India

Oral carcinoma is the most common malignancy found in adult Indian men and the third most common in adult Indian women. About half of all cases are found to be associated with precancerous lesions, chiefly leukoplakia. We wanted to explore the possible benefits of black tea (Camellia sinensis) administered to patients with oral leukoplakia. Eighty-two subjects with oral leukoplakia underwent micronuclei and chromosomal assays on exfoliated oral mucosal epithelium, after which they received black tea in a fixed regimen. The micronuclei assay was repeated at 6 months, and the chromosomal study at 1 year. After the first year, the first 15 patients entered onto this study showed a significant decrease in the micronuclei frequency and chromosomal aberrations, which correlated with the clinical improvement. Several in vitro and animal studies have suggested the efficacy of tea in the chemoprevention of cancer. To the best of our knowledge, this is the first report on the effect of black tea in oral leukoplakia.

DOI: 10.1615/JEnvPathToxOncol.v24.i2.70 Download article, 141-144 pages

Article price - $35.00

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