Journal of Environmental Pathology, Toxicology and Oncology

ISSN for PRINT: 0731-8898

For Online Access

Best Paper Award Selection - Editorial Board Site

2004, Volume23

Issue 4

88 pages

DOI: 10.1615/JEnvPathToxOncol.v23.i4

Issue price - $160.00

Yogeshwer Shukla
Environmental Carcinogenesis Division, Industrial Toxicology Research Centre,Lucknow, India

Pankaj Taneja
Environmental Carcinogenesis Division, Industrial Toxicology Research Centre, Lucknow, India

Annu Arora
Environmental Carcinogenesis Division, Industrial Toxicology Research Centre,Lucknow, India

Neeraj Sinha
Division of Toxicology, Central Drug Research Institute, Lucknow, India

Mancozeb, a dithiocarbamate fungicide, was examined for its possible mutagenic activity using Salmonella typhimurium tester strains TA97a, TA98, TA100, and TA102. We found that Mancozeb exhibited toxic effects at the dose of 40 μg/plate and higher with all tester strains. Mancozeb showed dose-dependent increases in the number of revertants with and without metabolic activation when it was dissolved in DMSO or acetone with strain TA97a; however, the number of revertants at the highest dose was less than two-fold compared to control values. We postulate that the true mutagenic potential of Mancozeb may be masked by its toxic effect to the tester strain used.

DOI: 10.1615/JEnvPathToxOncol.v23.i4.60 Download article, 6 pages

Article price - $35.00

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