Journal of Environmental Pathology, Toxicology and Oncology

ISSN for PRINT: 0731-8898

For Online Access

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2006, Volume25

Issue 4

94 pages

Issue price - $172.00

Inder Singh
Radiation and Cancer Biology Laboratory, Department of Zoology, University of Rajasthan, Jaipur, India

Dhanraj Soyal
Radiation and Cancer Biology Laboratory, Department of Zoology, University of Rajasthan, Jaipur - 302 004, India

Pradeep Kumar Goyal
Radiation and Cancer Biology Laboratory, Department of Zoology, University of Rajasthan, Jaipur - 302 004, India

Oral administration of Emblica officinalis (Linn.) before exposure to gamma radiation was found to be effective in protecting mice against the hematological and biochemical modulation in peripheral blood. A significant increase in the RBC, WBC, hemoglobin, and hematocrit values was observed in the animals pretreated with E. officinalis extract as compared to the hematological values observed in the irradiated group. Furthermore, radiation sickness was greatly inhibited in those mice that were irradiated with prior treatment of E. officinalis. A significant decrease in glutathione (GSH) content and increase in lipid peroxidation (LPx) level were also observed in irradiated animals; whereas E. officinalis pretreated irradiated animals exhibited a significant increase in GSH content and decrease in LPx level, but such remained below the normal. The results from the present study suggest that E. officinalis pretreatment provides protection against irradiation to Swiss albino mice.

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