Journal of Environmental Pathology, Toxicology and Oncology

ISSN for PRINT: 0731-8898

For Online Access

Best Paper Award Selection - Editorial Board Site

2001, Volume20

Issue 2

76 pages

Issue price - $160.00

Harinder M. Dani
Department of Biochemistry, Panjab University, Chandigarh, 160014, India

Parminder Kaur
Department of Biochemistry, Panjab University, Chandigarh-160014, India

We report here for the first time the optical visualization of microsomal degranulation induced by a carcinogen (p-dimethylaminoazobenzene), employing analytical ultracentrifugation.Our observations demonstrate that electrophiles of a carcinogen can disrupt ribosome-membrane interaction in rough microsomes by their attacks on nucleophilic components of the reticular membrane-ribosome complex involved in protein synthesis for export from the cytosol. Lack of exported proteins can adversely affect signal transduction across plasma membrane, possibly leading to carcinogenesis.

Download article, 3 pages

Article price - $35.00

<< Previous article   Next article >>