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Journal of Environmental Pathology, Toxicology and Oncology

ISSN for PRINT: 0731-8898

Institutional price:	$672.00
Issues per year:	4

Best Paper Award Selection - Editorial Board Site

2001, Volume20

76 pages

Issue price - $160.00

The Effect of Coenzyme Q₁₀ on Blood Ascorbic Acid, Vitamin E, and Lipid Peroxide in Chronic Cadmium Intoxication

Sladjan Z. Pavlovic
Department of Physiology, Institute for Biological Research Sinis.a Stankovic., Belgrade,Yugoslavia

Branka I. Ognjanovic
Institute of Biology, Faculty of Sciences, University of Kragujevac, Kragujevac, Yugoslavia

Andras S. Stajn
Institute of Biology, Faculty of Sciences, University of Kragujevac, Kragujevac, Yugoslavia

Radoslav V. Zikic
Institute of Biology, Faculty of Sciences, University of Kragujevac, Kragujevac, Yugoslavia

Zorica S. Saicic
Department of Physiology, Institute for Biological Research Sinis.a Stankovic., Belgrade,Yugoslavia

Vojislav M. Petrovic
Department of Physiology, Institute for Biological Research Sinis.a Stankovic., Belgrade,Yugoslavia

ABSTRACT

The aim of our study was to investigate the possible protective role of coenzyme Q₁₀ (CoQ₁₀) administration on ascorbic acid (AsA), vitamin E (vit E), and lipid peroxide (LP) concentrations in the blood of rats chronically treated with cadmium. Results were compared to those obtained in control animals, as well as to those obtained in animals treated with olive oil. Compared to that of the control animals, the AsA concentration was significantly increased in rats treated with CoQ₁₀ and olive oil, whereas vit E concentration was significantly increased in animals treated with cadmium, CoQ₁₀, or cadmium + CoQ₁₀. A significant decrease in LP concentration was noted in animals treated with cadmium or with cadmium + CoQ₁₀, whereas a significant increase was seen in animals treated with olive oil. Compared to that of the animals treated with olive oil, the ascorbic acid concentration was significantly decreased in rats treated with cadmium or with cadmium + CoQ₁₀, whereas vit E concentration was significantly increased in animals treated with cadmium,CoQ₁₀, or cadmium + CoQ₁₀. LP concentration was significantly decreased in rats treated with cadmium,CoQ₁₀, or cadmium + CoQ₁₀. Our study showed that CoQ₁₀ administration in rats chronically exposed to exogenous cadmium exerts beneficial effects on the nonenzymatic components of the antioxidant defense system, such as AsA and vit E, resulting in a decreased concentration of LP in the blood.