Journal of Environmental Pathology, Toxicology and Oncology

ISSN for PRINT: 0731-8898

For Online Access

Best Paper Award Selection - Editorial Board Site

2002, Volume21

Issue 2

124 pages

Issue price - $160.00

Toshihiko Kawamori
Cancer Prevention Division, National Cancer Center Research Institute, Tokyo 104-0045 Japan

Keiji Wakabayashi
Cancer Prevention Division, National Cancer Center Research Institute, Tokyo 104-0045 Japan

Accumulating evidence indicates that COX-2 inhibitors are involved in colon and breast cancer development. Our previous studies indicated that nimesulide and celecoxib, selective COX-2 inhibitors, show inhibitory effects of intestinal" carcinogenesis in azoxymethane-treated rats and mice and in Min mice models. We recently found that nimesulide suppressed PhIP-induced breast cancer in female SD rats in which COX-2 protein was overexpressed. These results led us to investigate the effects of prostaglandin E₂(PGE₂) in the target tissues. PGE₂ showed its biological activity through binding to its membrane receptors, EP_1~4. We also investigated the effects of EP receptors on colon carcinogenesis. We used receptor knockout mice and selective receptor antagonists. Our results indicated that the EP₁ receptor plays a pivotal role in colon carcinogenesis. Selective EP₁ receptor antagonists may be a new class of chemopreventive agents against colon cancer.

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