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Journal of Environmental Pathology, Toxicology and Oncology

ISSN for PRINT: 0731-8898

Institutional price:	$672.00
Issues per year:	4

Best Paper Award Selection - Editorial Board Site

2001, Volume20

90 pages

Issue price - $160.00

Elucidation of Tumor-Promoting Potential of a Combination Pesticide by Short-Term, In Vivo Bioassay

Prakya Balakrishnamurthy
Department of Toxicology, Fredrick Institute of Plant Protection and Toxicology (FIPPAT), Padappai 601 301, Tamil Nadu, India

Kalathil Sadasivan Pillai
Department of Toxicology, Fredrick Institute of Plant Protection and Toxicology (FIPPAT), Padappai 601 301, Tamil Nadu, India

E. Murali Mohan
Department of Toxicology, Fredrick Institute of Plant Protection and Toxicology (FIPPAT), Padappai 601 301, Tamil Nadu, India

M. Rajaram Gayathri
Department of Toxicology, Fredrick Institute of Plant Protection and Toxicology (FIPPAT), Padappai 601 301, Tamil Nadu, India

D. Amirtha Ganesh
Department of Toxicology, Fredrick Institute of Plant Protection and Toxicology (FIPPAT), Padappai 601 301, Tamil Nadu, India

C. A. Y. Banu Priya
Department of Toxicology, Fredrick Institute of Plant Protection and Toxicology (FIPPAT), Padappai 601 301, Tamil Nadu, India

A. Arun Sam Lal
Department of Toxicology, Fredrick Institute of Plant Protection and Toxicology (FIPPAT), Padappai 601 301, Tamil Nadu, India

V. Amalan Stanley
Department of Toxicology, Fredrick Institute of Plant Protection and Toxicology (FIPPAT), Padappai 601 301, Tamil Nadu, India

ABSTRACT

The use of combination pesticide (profenofos 40% + cypermethrin 4% EC) is on the rise in India and elsewhere. Cypermethrin is reported to be a tumor promoter, but its tumor-promoting potential along with profenofos is yet to be studied. A short-term, in vivo test for detection of a tumor promoter is cost-effective, saves time, and requires fewer animals than conventional methods. We report on a short-term test based on mechanisms of significant importance in tumor promotion. In this study, we have tested the tumor-promoting potential of a combination pesticide containing profenofos 40% and cypermethrin 4% EC in Wistar rats. Although cypermethrin has been reported as a tumor promoter, our study shows that the combination pesticide containing profenofos 40% and cypermethrin 4% EC is not a tumor promoter.