Journal of Environmental Pathology, Toxicology and Oncology

ISSN for PRINT: 0731-8898

For Online Access

Best Paper Award Selection - Editorial Board Site

2001, Volume20

Issue 3

90 pages

Issue price - $160.00

Monisha Sundarrajan
Cellular Carcinoge'nesis Laboratory, Cancer Research Institute, Tata Memorial Centre,. Parel, Mumbai, India

Aaron Z. Fernandis
Biotechnology Centre, Indian Institute of Technology, Powai, Mumbai, India

Gosukonda Subrahmanyam
Biotechnology Centre, Indian Institute of Technology, Powai, Mumbai, India

Shilpa Prabhudesai
Department of Pathology, Tata Memorial Hospital, Tata Memorial Centre, Parel, Mumbai, India

Shanta C. Krishnamurthy
Department of Pathology, Tata Memorial Hospital, Tata Memorial Centre, Parel, Mumbai, India

K. V. K. Rao
Cellular Carcinogenesis Laboratory, Cancer Research Institute, Tata Memorial Centre, Parel, Mumbai 400012, India

It is now widely accepted that cancer development is a multistage process, starting from the original cell population and ending with a malignant tumor. However, the mechanisms involved in the progressive growth of cells from normalcy to preneoplasia, and from preneoplasia to malignancy are not clear. Because tyrosine phosphorylation and dephosphorylation reactions are known to play critical roles during normal and abnormal cellular growth, we have studied the tyrosine phosphorylation, tyrosine phosphorylated proteins, and protein phos-phatases during the sequential development of liver cancer. The present investigation indicated that enhanced tyrosine phosphorylation and tyrosine phosphorylated proteins, with no change in the levels of tyrosine protein phosphatases may contribute to abnormal cellular proliferation during liver carcinogenesis. We have also seen an increase in the expression of proliferating cell nuclear antigen and G1/S cyclins during tumor development.

Download article, 9 pages

Article price - $35.00

<< Previous article   Next article >>