Journal of Environmental Pathology, Toxicology and Oncology

ISSN for PRINT: 0731-8898

For Online Access

Best Paper Award Selection - Editorial Board Site

2003, Volume22

Issue 1

82 pages

DOI: 10.1615/JEnvPathToxOncol.v22.i1

Issue price - $160.00

Swayamjot Kaur
Department of Botanical Sciences, Guru Nanak Dev University, Amritsar, Punjab, India

Saroj Arora
Department of Botanical Sciences, Guru Nanak Dev University, Amritsar 143 005, Punjab, India

Satwinderjeet Kaur
Department of Botanical Sciences, Guru Nanak Dev University, Amritsar, India

Subodh Kumar
Department of Chemistry, Guru Nanak Dev University, Amritsar, Punjab, India

In the course of our search for novel polyphenolic antimutagenic agents from medicinal plants, we examined water, acetone, and chloroform extracts of Terminalia bellerica for their antimutagenic potency using the Ames Salmonella/microsome assay. Acetone extract exhibited variable inhibitory activity of 65.6%, and 69.7% with 4–O–nitrophenylenediamine (NPD) and sodium azide, respectively (as direct-acting mutagens), and 81.4% with 2–aminofluorene (2AF) (an S9-dependent mutagen), in the preincubation mode of experimentation. Inhibition with chloroform and water extracts was rather insignificant. Studies are well underway to isolate and identify the active polyphenolic compounds from acetone extract, which could be used as effective chemopreventive agents in the future.

DOI: 10.1615/JEnvPathToxOncol.v22.i1.70 Download article, 8 pages

Article price - $35.00

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