Journal of Environmental Pathology, Toxicology and Oncology

ISSN for PRINT: 0731-8898

For Online Access

Best Paper Award Selection - Editorial Board Site

2004, Volume23

Issue 2

90 pages

DOI: 10.1615/JEnvPathToxOncol.v23.i2

Issue price - $160.00

Arnaud Boissiere
Groupe de Physique des Solides, Universites Paris 6 et Paris 7, Paris, France

Anne Eschenbrenner
Groupe de Physique des Solides, Universites Paris 6 et Paris 7, Paris, France

Francois Gobert
Groupe de Physique des Solides, Universites Paris 6 et Paris 7, Paris, France

Marie-Anne Herve du Penhoat
Groupe de Physique des Solides, Universites Paris 6 et Paris 7, Paris, France

Francois Abel
Groupe de Physique des Solides, Universites Paris 6 et Paris 7, Paris, France

Michele Lamoureux
Groupe de Physique des Solides, Universites Paris 6 et Paris 7, Paris, France

Luis Martins
Laboratoire de Radiobiologie et Oncologie, Fontenay aux Roses, France

Marie-Francoise Politis
Groupe de Physique des Solides, Universites Paris 6 et Paris 7, Paris, France

Michele Ricoul
Laboratoire de Radiobiologie et Oncologie, Fontenay aux Roses, France

Alain Touati
Groupe de Physique des Solides, Universites Paris 6 et Paris 7, Paris, France

Evelyne Sage
Laboratoire de Genotoxicite et Modulation de l'Expression Genique, Institut Curie Recherche, Orsay, France

Laure Sabatier
Laboratoire de Radiobiologie et Oncologie, Fontenay aux Roses, France

Annie Chetioui
Groupe de Physique des Solides, Universites Paris 6 et Paris 7, Paris, France

It has been proposed that unrepaired or misrepaired complex lesions of DNA are responsible for cell inactivation and chromosomal aberrations. The detailed features of the critical damage and the nature of initiating physical events are actively investigated. We studied the role of inner-shell (core) ionizations in DNA atoms is studied. Ultrasoft X-rays from LURE synchrotron radiation have been used to mimic core events induced by ionizing radiations. For biological matter, inner-shell photoionization is indeed the main interaction channel of these radiations. Moreover, by tuning the X-ray energy below and above the carbon K-threshold, it is possible to achieve a two-fold increase in the number of core-ionizations in DNA for a same dose. Cell survival and chromosome aberrations have thus been studied at three iso-attenuated energies: 250,350, and 810 eV. Relative biological efficiencies (RBEs) for cell inactivation and chromosome aberrations were found to be strongly correlated with the yields of core events in DNA.

DOI: 10.1615/JEnvPathToxOncol.v23.i2.30 Download article, 10 pages

Article price - $35.00

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