Journal of Environmental Pathology, Toxicology and Oncology

ISSN for PRINT: 0731-8898

For Online Access

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2007, Volume26

Issue 3

82 pages

Issue price - $187.00

Vandana Nunia
Radiation & Cancer Biology Laboratory, Department of Zoology, University of Rajasthan, Jaipur—302 004, India

Pradeep Kumar Goyal
Radiation and Cancer Biology Laboratory, Department of Zoology, University of Rajasthan, Jaipur - 302 004, India

Protective efficacy of diltiazem (a calcium channel blocker) has been studied against cadmium chloride (CdCl₂) induced hematological and biochemical alterations in Swiss albino mice. CdCl₂ (5 mg/kg b.wt.; i.p.) with or without prior treatment of diltiazem (100 mg/kg b. wt.; i.p.) was given to six-week old mice. Significant increase in the number of bone marrow cells as well as hematological parameters was observed in diltiazem pretreated CdCl₂ intoxicated animals. A significant increase in lipid peroxidation (LPO) and acid phosphatase (ACP) level, and decrease in glutathione (GSH) and alkaline phosphatase (ALP) level in blood as well as liver were measured in CdCl₂ intoxicated mice, while such values were near normal in DTZ pretreated animals. Furthermore, a significant increase in erythropoeitin (EPO) level was observed in diltiazem (DTZ) pretreated CdCl₂ intoxicated animals as compared to CdCl₂ alone treated animals. Thus, Diltiazem administration before cadmium intoxication protects bone marrow and hematological constituents in mice.

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