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Journal of Long-Term Effects of Medical Implants

ISSN for PRINT: 1050-6934

Institutional price:	$1021.00
Issues per year:	6

Best Paper Award Selection - Editorial Board Site

2001, Volume11

110 pages

Issue price - $350.00

PART 3. GENERAL ARTICLE
Long-Term Follow-Up Study of Bioactive Bone Cement for Repairing a Segmental Defect in a Canine Femur

Shunsuke Fujibayashi, M.D.
Department of Orthopaedic Surgery, Graduate School of Medicine, Kyoto University, Shogoin-kawahara-cho 54, Sakyo-ku, Kyoto 606-8507, Japan

Yoshinaga Senaha, M.D., D.M.S.C.
Department of Orthopaedic Surgery, Graduate School of Medicine, Kyoto University, Shogoin-kawahara-cho 54, Sakyo-ku, Kyoto 606-8507, Japan

Satoshi Yoshihara
Nippon Electric Glass Co. Ltd., Seiran 2-7-1, Otsu 520-8639, Japan

Jiro Tamura, M.D., D.M.S.C.
Department of Orthopaedic Surgery, Graduate School of Medicine, Kyoto University, Shogoin-kawahara-cho 54, Sakyo-ku, Kyoto 606-8507, Japan

Takashi Nakamura, M.D., D.M.S.C.
Department of Orthopaedic Surgery, Graduate School of Medicine, Kyoto University, Shogoin-kawahara-cho 54, Sakyo-ku, Kyoto 606-8507, Japan

ABSTRACT

We report on a 7-year long-term follow-up study of a bioactive bone cement (BA cement) that was used to repair a segmental defect in a canine femur. Bilateral femoral segmental defects were repaired with metallic implants that were fixed to the femur using two kinds of bone cement. The BA cement used in this study consists of an apatite- and wollastonite-containing glass ceramic (AW-GC) with a bis-phenol-α-glycidyl methacrylate (bis-GMA)-based resin. The bone-cement interface was examined histologically. Previous short-term studies have shown that using BA cement for segmental replacement of the canine femur produced excellent biomechanical and histological results. The BA cement maintained the fixation of a metallic implant to the femur very well. In contrast, the PMMA cement did not maintain alignment under long-term weight-bearing conditions. The results of histological examinations showed direct bonding between the BA cement and bone, while an intervening soft tissue layer was observed at the bone-cement interface with the PMMA cement. The BA cement bonded to the bone through a Ca-P-rich reactive layer, which was twice as thick after 7 years than it was at 26 weeks. No adverse effects of BA cement were observed during the 7-year observation period.