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Journal of Long-Term Effects of Medical Implants

 

ISSN for PRINT: 1050-6934

Institutional price:

$1021.00

Issues per year:

6

For Online Access

Best Paper Award Selection - Editorial Board Site

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2002, Volume12

Issue 2

  96 pages  

   

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Issue price - $175.00  

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  • DNA Strand Gene Transfer and Bone Healing
  • William C. Lineaweaver, MD
    Division of Plastic Surgery. The University of Mississippi Medical Center, 2500, North State Street, Jackson, MS 39216-4505

    Feng Zhang
    Division of Plastic Surgery, Microsurgery Laboratory, University of Mississippi Medical Center, 2500 North State Street, Jackson, MS 39216

    Kenneth Fischer, M.D.
    Division of Plastic Surgery, University of Mississippi Medical Center, 2500 North State Street, Jackson, MS 39216


    ABSTRACT

    Continued research is still needed to broaden the understanding of the biology of bone formation, bone repair, and bone remodeling. Preliminary data reviewed in this article confirm that it is possible to use ex vivo and in vrvo gene-transfer strategies to transfer genes to bone and express them in the repair site. As work progresses, strategies of gene therapy with osteoinductive-growth factors may provide the orthopedic surgeon with more effective and less-costly treatment options for bone-healing problems.

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