ITEMS

modern scholarly publishers in the finest tradition

Journals

	Search

Journal of Long-Term Effects of Medical Implants

ISSN for PRINT: 1050-6934

Institutional price:	$1021.00
Issues per year:	6

Best Paper Award Selection - Editorial Board Site

2003, Volume13

84 pages

DOI: 10.1615/JLongTermEffMedImplants.v13.i5

Issue price - $175.00

Fibrin Sealant Reduces Perioperative Blood Loss in Total Hip Replacement

Gwo-Jaw Wang
Department of Orthopaedic Surgery, University of Virginia, Charlottesville, Virginia, USA

Charles A. Goldthwaite, Jr., PhD
Surgical Therapeutic Advancement Center, University of Virginia, Charlottesville, Virginia, USA

Sandra G. Burks, BSN, RN
Surgical Therapeutic Advancement Center, University of Virginia, Charlottesville, Virginia, USA

Ross Crawford, MD
Department of Biomedical Engineering, University of Technology, Queensland, Australia

William D. Spotnitz
Division of Thoracic and Cardiovascular Surgery, University of Florida; Surgical Therapeutic Advancement Center, University of Virginia, Charlottesville, Virginia, USA

ABSTRACT

Patients (n = 81) undergoing total hip replacement (THR) were randomized to receive either standard of care plus fibrin sealant (FS) (10 mL total) or standard of care alone to evaluate the efficacy of FS for reducing blood loss in THR. Considering the 81 intent-to-treat patients, adjusted perioperative blood loss was reduced significantly in the FS group, by 197 mL [95% CI: 45 mL, 319 mL] or 23.5% [95% CI: 5.4%, 38.1%] (p = 0.014). When protocol violators were eliminated, leaving 73 patients, the adjusted FS group perioperative bleeding was reduced by 221 mL [95% CI: 63 mL, 351 mL] or 27.1% [95% CI: 7.6%, 42.5%] (p = 0.0098).