Critical Reviews™ in Immunology

ISSN for PRINT: 1040-8401

For Online Access

Best Paper Award Selection - Editorial Board Site

2007, Volume27

Issue 2

124 pages

Issue price - $153.00

Daniel J. Moore
Harrison Department of Surgical Research, Department of Surgery, University of Pennsylvania; present address: Department of Pediatrics, Vanderbilt University, Nashville, TN 37232

James I. Kim
Harrison Department of Surgical Research, Department of Surgery, University of Pennsylvania

Samsher Sonawane
Harrison Department of Surgical Research, Department of Surgery, University of Pennsylvania

Heidi Yeh
Harrison Department of Surgical Research, Department of Surgery, University of Pennsylvania

Shaoping Deng
Harrison Department of Surgical Research, Department of Surgery, University of Pennsylvania

Major Kenneth Lee IV
Harrison Department of Surgical Research, Department of Surgery, University of Pennsylvania

James F. Markmann
Harrison Department of Surgical Research, Department of Surgery, University of Pennsylvania

Transplantation tolerance remains an elusive goal. Despite multiple animal models of tolerance induction using a variety of agents and protocols, it has yet to be achieved in humans with any predictability. In this review, we examine some of the antibodies directed toward T cells that show promise in prolonging graft survival in animal models and in preliminary clinical assessment. Because these antibodies work through multiple pathways, including depletion, downregulation, receptor-ligand blockade, and direct signaling, they have also helped us tease out the various components of long-lived donor-specific tolerance. In particular, we review the role of the thymus in therapies targeted at the peripheral immune system; the importance of the thymus in tolerance induced by anti-CD45RB suggests that central tolerance mechanisms may be more important than previously appreciated.

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