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Critical Reviews™ in Immunology

ISSN for PRINT: 1040-8401

Institutional price:	$831.00
Issues per year:	6

Best Paper Award Selection - Editorial Board Site

2004, Volume24

69 pages

DOI: 10.1615/CritRevImmunol.v24.i4

Issue price - $132.00

Negative Regulation of T-Cell Function by PD-1

Yuan yuan Zha
University of Chicago, Department of Pathology and Department of Medicine, Section of Hematology/ Oncology, Chicago, IL 60637

Christian Blank
University of Chicago, Department of Pathology and Department of Medicine, Section of Hematology/ Oncology, Chicago, IL 60637

Thomas F. Gajewski
University of Chicago, Department of Pathology and Department of Medicine, Section of Hematology/ Oncology, Chicago, IL 60637

ABSTRACT

PD-1 is a receptor inducibly expressed on CD4⁺ and CD8⁺ T cells Mowing activation. PD-1-deficient mice develop signs of autoimmunity, suggesting a negative regulatory role for PD-1 in dampening lymphocyte responses. The expression of one ligand for PD-1, designated PD-L1 or B7-H1, on tumor cells of a variety of histologies has suggested a potential mechanism for tumor escape from immune destruction. This review summarizes data regarding PD-1 and related negative regulatory receptors, focusing on implications for potentiating antitumor immunity in vivo.