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Critical Reviews™ in Immunology

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ISSN Print: 1040-8401

ISSN Online: 2162-6472

The Impact Factor measures the average number of citations received in a particular year by papers published in the journal during the two preceding years. 2017 Journal Citation Reports (Clarivate Analytics, 2018) IF: 1.3 To calculate the five year Impact Factor, citations are counted in 2017 to the previous five years and divided by the source items published in the previous five years. 2017 Journal Citation Reports (Clarivate Analytics, 2018) 5-Year IF: 2.6 The Eigenfactor score, developed by Jevin West and Carl Bergstrom at the University of Washington, is a rating of the total importance of a scientific journal. Journals are rated according to the number of incoming citations, with citations from highly ranked journals weighted to make a larger contribution to the eigenfactor than those from poorly ranked journals. Eigenfactor: 0.00079 The Journal Citation Indicator (JCI) is a single measurement of the field-normalized citation impact of journals in the Web of Science Core Collection across disciplines. The key words here are that the metric is normalized and cross-disciplinary. JCI: 0.24 SJR: 0.429 SNIP: 0.287 CiteScore™:: 2.7 H-Index: 81

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TCR Trafficking in Resting and Stimulated T Cells

Volume 24, Issue 1, 2004, 20 pages
DOI: 10.1615/CritRevImmunol.v24.i1.30
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ABSTRACT

Dynamic regulation of TCR expression levels plays important roles in modulating T-cell responses during T-cell development and in mature T cells. TCR expression levels are determined by the rate constants for synthesis, endocytosis, recycling, and degradation. This review examines the rate constants, the molecular mechanisms, and the proposed physiological roles of TCR trafficking in resting and stimulated T cells. In resting T cells, the TCR slowly and constitutively cycles between the plasma membrane and the intracellular compartment. Constitutive TCR cycling is dependent on the di-leucine-based (diL) receptor-sorting motif in the TCR subunit CD3g and might play a role in quality control of the TCR. TCR triggering induces an enhancement in the endocytic rate constant leading to TCR down-regulation. At least two pathways exist for endocytosis of triggered TCR. One is dependent on protein tyrosine kinase activity leading to ubiquitination of the TCR, whereas the other is dependent on protein kinase C (PKC)-mediated activation of the diL motif. In addition, nontriggered TCR are endocytosed (co-modulated) by the PKC/CD3g-dependent pathway. TCR down-regulation might attenuate signaling and/or might ensure an internal store of TCR that can be rerouted to the immunological synapse during the encounter with an antigen-presenting cell.

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  1. Tucker Torry A., Schwiebert Lisa M., CD40 ligation decreases its protein half-lifeat the cell surface, European Journal of Immunology, 38, 3, 2008. Crossref

  2. Finetti Francesca, Paccani Silvia Rossi, Riparbelli Maria Giovanna, Giacomello Emiliana, Perinetti Giuseppe, Pazour Gregory J., Rosenbaum Joel L., Baldari Cosima T., Intraflagellar transport is required for polarized recycling of the TCR/CD3 complex to the immune synapse, Nature Cell Biology, 11, 11, 2009. Crossref

  3. Hollier Mark, Whistler Toni, Dawson Carolyn, Vernon Suzanne D., Two optimized combination assays to examine apoptosis pathways in clinical samples, Cytometry Part A, 71A, 9, 2007. Crossref

  4. Balagopalan Lakshmi, Barr Valarie A., Samelson Lawrence E., Endocytic events in TCR signaling: focus on adapters in microclusters, Immunological Reviews, 232, 1, 2009. Crossref

  5. Schmidt-Mende Jan, Geering Barbara, Yousefi Shida, Simon Hans-Uwe, Lysosomal degradation of RhoH protein upon antigen receptor activation in T but not B cells, European Journal of Immunology, 40, 2, 2010. Crossref

  6. Masilamani Madhan, Peruzzi Giovanna, Borrego Francisco, Coligan John E., Endocytosis and Intracellular Trafficking of Human Natural Killer Cell Receptors, Traffic, 10, 12, 2009. Crossref

  7. Ghosh Dhimankrishna, Lippert Dustin, Krokhin Oleg, Cortens John P., Wilkins John A., Defining the membrane proteome of NK cells, Journal of Mass Spectrometry, 2009. Crossref

  8. Kohrt Holbrook E, Shu Chen-Tsen, Stuge Tor B, Holmes Susan P, Weber Jeffrey, Lee Peter P, Rapid Assessment of Recognition Efficiency and Functional Capacity of Antigen-Specific T-Cell Responses, Journal of Immunotherapy, 28, 4, 2005. Crossref

  9. McLaughlin Bridget E., Baumgarth Nicole, Bigos Martin, Roederer Mario, De Rosa Stephen C., Altman John D., Nixon Douglas F., Ottinger Janet, Oxford Carol, Evans Thomas G., Asmuth David M., Nine-color flow cytometry for accurate measurement of T cell subsets and cytokine responses. Part I: Panel design by an empiric approach, Cytometry Part A, 73A, 5, 2008. Crossref

  10. Dave Vibhuti P., Hierarchical role of CD3 chains in thymocyte development, Immunological Reviews, 232, 1, 2009. Crossref

  11. Rajagopalan Sumati, Endosomal Signaling and a Novel Pathway Defined by the Natural Killer Receptor KIR2DL4 (CD158d), Traffic, 11, 11, 2010. Crossref

  12. Muratori Claudia, Cavallin Lucas E., Krätzel Kirsten, Tinari Antonella, De Milito Angelo, Fais Stefano, D'Aloja Paola, Federico Maurizio, Vullo Vincenzo, Fomina Alla, Mesri Enrique A., Superti Fabiana, Baur Andreas S., Massive Secretion by T Cells Is Caused by HIV Nef in Infected Cells and by Nef Transfer to Bystander Cells, Cell Host & Microbe, 6, 3, 2009. Crossref

  13. Simmons Kalynn B., Wubeshet Maramawit, Ames Kristina T., McMahan Catherine J., Hale J. Scott, Fink Pamela J., Modulation of TCRβ surface expression during TCR revision, Cellular Immunology, 272, 2, 2012. Crossref

  14. Carpino Nick, Chen Yunting, Nassar Nicolas, Oh Hye-Won, The Sts proteins target tyrosine phosphorylated, ubiquitinated proteins within TCR signaling pathways, Molecular Immunology, 46, 16, 2009. Crossref

  15. Ouchida Rika, Yamasaki Sho, Hikida Masaki, Masuda Keiji, Kawamura Kiyoko, Wada Akihiko, Mochizuki Shigenobu, Tagawa Masatoshi, Sakamoto Akemi, Hatano Masahiko, Tokuhisa Takeshi, Koseki Haruhiko, Saito Takashi, Kurosaki Tomohiro, Wang Ji-Yang, A Lysosomal Protein Negatively Regulates Surface T Cell Antigen Receptor Expression by Promoting CD3ζ-Chain Degradation, Immunity, 29, 1, 2008. Crossref

  16. Fattakhova Gul’nar V., Masilamani Madhan, Narayanan Sriram, Borrego Francisco, Gilfillan Alasdair M., Metcalfe Dean D., Coligan John E., Endosomal trafficking of the ligated FcɛRI receptor, Molecular Immunology, 46, 5, 2009. Crossref

  17. Hansen Ann K., Regner Matthias, Bonefeld Charlotte M., Boding Lasse, Kongsbak Martin, Ødum Niels, Müllbacher Arno, Geisler Carsten, von Essen Marina R., TCR down-regulation boosts T-cell-mediated cytotoxicity and protection against poxvirus infections, European Journal of Immunology, 41, 7, 2011. Crossref

  18. Miscia Sebastiano, Ciccocioppo Fausta, Lanuti Paola, Velluto Lucia, Bascelli Adriana, Pierdomenico Laura, Genovesi Domenico, Di Siena Alessandro, Santavenere Eugenio, Gambi Francesco, Ausili-Cèfaro Giampiero, Grimley Philip M., Marchisio Marco, Gambi Domenico, Aβ1–42 stimulated T cells express P-PKC-δ and P-PKC-ζ in Alzheimer disease, Neurobiology of Aging, 30, 3, 2009. Crossref

  19. Finetti Francesca, Paccani Silvia Rossi, Rosenbaum Joel, Baldari Cosima T., Intraflagellar transport: a new player at the immune synapse, Trends in Immunology, 32, 4, 2011. Crossref

  20. Takeuchi Koh, Yang Hailin, Ng Elise, Park Sungh-youk, Sun Zhen-Yu J., Reinherz Ellis L., Wagner Gerhard, Structural and Functional Evidence that Nck Interaction with CD3ε Regulates T-Cell Receptor Activity, Journal of Molecular Biology, 380, 4, 2008. Crossref

  21. Lauritsen Jens Peter H., Bonefeld Charlotte Menné, von Essen Marina, Nielsen Martin Weiss, Rasmussen Anette Bødker, Ødum Niels, Dietrich Jes, Geisler Carsten, Masking of the CD3γ di-Leucine-based Motif by ζ is Required for Efficient T-Cell Receptor Expression, Traffic, 5, 9, 2004. Crossref

  22. Finetti Francesca, Baldari Cosima T., Compartmentalization of signaling by vesicular trafficking: a shared building design for the immune synapse and the primary cilium, Immunological Reviews, 251, 1, 2013. Crossref

  23. Wang Chunxia, Maass Thorsten, Krupp Markus, Thieringer Florian, Strand Susanne, Wörns Marcus A., Barreiros Ana-Paula, Galle Peter R., Teufel Andreas, A systems biology perspective on cholangiocellular carcinoma development: Focus on MAPK-signaling and the extracellular environment, Journal of Hepatology, 50, 6, 2009. Crossref

  24. Barr Valarie A., Balagopalan Lakshmi, Barda-Saad Mira, Polishchuk Roman, Boukari Hacène, Bunnell Stephen C., Bernot Kelsie M., Toda Yoko, Nossal Ralph, Samelson Lawrence E., T-Cell Antigen Receptor-Induced Signaling Complexes: Internalization Via a Cholesterol-Dependent Endocytic Pathway, Traffic, 7, 9, 2006. Crossref

  25. Arkhipov Sergey N., Maly Ivan V., Quantitative Analysis of the Role of Receptor Recycling in T Cell Polarization, Biophysical Journal, 91, 11, 2006. Crossref

  26. von Essen Marina Rode, Kongsbak Martin, Levring Trine Bøegh, Hansen Ann Kathrine, Boding Lasse, Lauritsen Jens Peter Holst, Woetmann Anders, Baier Gottfried, Ødum Niels, Bonefeld Charlotte Menné, Geisler Carsten, PKC-θ exists in an oxidized inactive form in naive human T cells, European Journal of Immunology, 43, 6, 2013. Crossref

  27. Kawai Yohei, Ouchida Rika, Yamasaki Sho, Dragone Leonard, Tsubata Takeshi, Wang Ji‐Yang, LAPTM5 promotes lysosomal degradation of intracellular CD3ζ but not of cell surface CD3ζ, Immunology & Cell Biology, 92, 6, 2014. Crossref

  28. Czopik Agnieszka K., Bynoe Margaret S., Palm Noah, Raine Cedric S., Medzhitov Ruslan, Semaphorin 7A Is a Negative Regulator of T Cell Responses, Immunity, 24, 5, 2006. Crossref

  29. Onnis A, Finetti F, Patrussi L, Gottardo M, Cassioli C, Spanò S, Baldari C T, The small GTPase Rab29 is a common regulator of immune synapse assembly and ciliogenesis, Cell Death & Differentiation, 22, 10, 2015. Crossref

  30. Lou Jieqiong, Rossy Jérémie, Deng Qiji, Pageon Sophie V., Gaus Katharina, New Insights into How Trafficking Regulates T Cell Receptor Signaling, Frontiers in Cell and Developmental Biology, 4, 2016. Crossref

  31. Tanase Carmen-Alexandra, Dalmasso Guillaume, Histidine Domain-Protein Tyrosine Phosphatase Interacts with Grb2 and GrpL, PLoS ONE, 5, 12, 2010. Crossref

  32. Cernuda-Morollón Eva, Millán Jaime, Shipman Mark, Marelli-Berg Federica M., Ridley Anne J., Arkowitz Robert Alan, Rac Activation by the T-Cell Receptor Inhibits T Cell Migration, PLoS ONE, 5, 8, 2010. Crossref

  33. Khan Manzoor M., Overview of the Immune Response, in Immunopharmacology, 2016. Crossref

  34. Onnis Anna, Finetti Francesca, Baldari Cosima T., Vesicular Trafficking to the Immune Synapse: How to Assemble Receptor-Tailored Pathways from a Basic Building Set, Frontiers in Immunology, 7, 2016. Crossref

  35. Yang Chiao-Wen, Hojer Caroline D., Zhou Meijuan, Wu Xiumin, Wuster Arthur, Lee Wyne P., Yaspan Brian L., Chan Andrew C., Regulation of T Cell Receptor Signaling by DENND1B in T H 2 Cells and Allergic Disease, Cell, 164, 1-2, 2016. Crossref

  36. Ali Qasim, Mustafa Ibrahim H., Elkamel Ali, Touboul Eric, Gruy Frederic, Lambert Claude, Mathematical modelling of T-cells activation dynamics for CD3 molecules recycling process, The Canadian Journal of Chemical Engineering, 94, 12, 2016. Crossref

  37. Perley Jeffrey, Mikolajczak Judith, Buzzard Gregery, Harrison Marietta, Rundell Ann, Resolving Early Signaling Events in T-Cell Activation Leading to IL-2 and FOXP3 Transcription, Processes, 2, 4, 2014. Crossref

  38. Arkhipov Sergey N., Maly Ivan V., Hotchin Neil, A Model for the Interplay of Receptor Recycling and Receptor-Mediated Contact in T Cells, PLoS ONE, 2, 7, 2007. Crossref

  39. Zhang Ye, Shen Hao, Liu Haifeng, Feng Haiyun, Liu Yan, Zhu Xiaoyan, Liu Xiaolong, Arp2/3 complex controls T cell homeostasis by maintaining surface TCR levels via regulating TCR+ endosome trafficking, Scientific Reports, 7, 1, 2017. Crossref

  40. Dong Guangyu, Kalifa Rachel, Nath Pulak Ranjan, Babichev Yael, Gelkop Sigal, Isakov Noah, Crk adaptor proteins regulate CD3ζ chain phosphorylation and TCR/CD3 down-modulation in activated T cells, Cellular Signalling, 36, 2017. Crossref

  41. Simons Michael, An Inside View: VEGF Receptor Trafficking and Signaling, Physiology, 27, 4, 2012. Crossref

  42. Patrussi Laura, Baldari Cosima T., Analysis of TCR/CD3 Recycling at the Immune Synapse, in The Immune Synapse, 1584, 2017. Crossref

  43. Jee Mia Hamilton, Johansen Jeanne Duus, Buus Terkild Brink, Petersen Trine Hilkjær, Gadsbøll Anne-Sofie Østergaard, Woetmann Anders, Ødum Niels, Thyssen Jacob Pontoppidan, White Andrea Jane, Anderson Graham, Geisler Carsten, Bonefeld Charlotte Menné, Increased Production of IL-17A-Producing γδ T Cells in the Thymus of Filaggrin-Deficient Mice, Frontiers in Immunology, 9, 2018. Crossref

  44. Rojo Jose M., Ojeda Gloria, Acosta Yenny Y., Montes-Casado Maria, Criado Gabriel, Portolés Pilar, Characteristics of TCR/CD3 complex CD3ɛ chains of regulatory CD4+ T (Treg) lymphocytes: role in Treg differentiation in vitro and impact on Treg in vivo, Journal of Leukocyte Biology, 95, 3, 2014. Crossref

  45. von Essen Marina, Nielsen Martin W., Bonefeld Charlotte M., Boding Lasse, Larsen Jeppe M., Leitges Michael, Baier Gottfried, Ødum Niels, Geisler Carsten, Protein Kinase C (PKC)α and PKCθ Are the Major PKC Isotypes Involved in TCR Down-Regulation, The Journal of Immunology, 176, 12, 2006. Crossref

  46. Boding Lasse, Bonefeld Charlotte Menné, Nielsen Bodil L., Lauritsen Jens Peter H., von Essen Marina Rode, Hansen Ann Kathrine, Larsen Jeppe Madura, Nielsen Morten Milek, Ødum Niels, Geisler Carsten, TCR Down-Regulation Controls T Cell Homeostasis, The Journal of Immunology, 183, 8, 2009. Crossref

  47. Onnis Anna, Baldari Cosima T., Orchestration of Immunological Synapse Assembly by Vesicular Trafficking, Frontiers in Cell and Developmental Biology, 7, 2019. Crossref

  48. Stokes Alexander, Wakano Clay, Koblan-Huberson Murielle, Adra Chaker N., Fleig Andrea, Turner Helen, TRPA1 is a substrate for de-ubiquitination by the tumor suppressor CYLD, Cellular Signalling, 18, 10, 2006. Crossref

  49. Ge Yan, Paisie Taylor K., Chen Sixue, Concannon Patrick, UBASH3A Regulates the Synthesis and Dynamics of TCR–CD3 Complexes, The Journal of Immunology, 203, 11, 2019. Crossref

  50. Doherty Melissa, Osborne Douglas G., Browning Diana L., Parker David C., Wetzel Scott A., Anergic CD4+ T Cells Form Mature Immunological Synapses with Enhanced Accumulation of c-Cbl and Cbl-b, The Journal of Immunology, 184, 7, 2010. Crossref

  51. von Essen Marina, Bonefeld Charlotte Menné, Siersma Volkert, Rasmussen Anette Bødker, Lauritsen Jens Peter H., Nielsen Bodil L., Geisler Carsten, Constitutive and Ligand-Induced TCR Degradation, The Journal of Immunology, 173, 1, 2004. Crossref

  52. Bonefeld Charlotte Menné, Haks Mariëlle, Nielsen Bodil, von Essen Marina, Boding Lasse, Hansen Ann Kathrine, Larsen Jeppe Madura, Ødum Niels, Krimpenfort Paul, Kruisbeek Ada, Christensen Jan Pravsgaard, Thomsen Allan Randrup, Geisler Carsten, TCR Down-Regulation Controls Virus-Specific CD8+T Cell Responses, The Journal of Immunology, 181, 11, 2008. Crossref

  53. Clift Ian C., Bamidele Adebowale O., Rodriguez-Ramirez Christie, Kremer Kimberly N., Hedin Karen E., β-Arrestin1 and Distinct CXCR4 Structures Are Required for Stromal Derived Factor-1 to Downregulate CXCR4 Cell-Surface Levels in Neuroblastoma, Molecular Pharmacology, 85, 4, 2014. Crossref

  54. Mincheva-Nilsson Lucia, Baranov Vladimir, The Nature and Role of the Decidual T Cells, in Immunology of Pregnancy, 2006. Crossref

  55. Khan Manzoor M., Overview of the Immune Response, in Immunopharmacology, 2008. Crossref

  56. Kim Myles, A numerical mechanical model integrating actin treadmilling and receptor recycling to explain selective disengagement of immune cells, Mathematical Biosciences, 316, 2019. Crossref

  57. Li Qing, So Christopher R., Fegan Adrian, Cody Vivian, Sarikaya Mehmet, Vallera Daniel A., Wagner Carston R., Chemically Self-Assembled Antibody Nanorings (CSANs): Design and Characterization of an Anti-CD3 IgM Biomimetic, Journal of the American Chemical Society, 132, 48, 2010. Crossref

  58. Call Matthew E., Wucherpfennig Kai W., THE T CELL RECEPTOR: Critical Role of the Membrane Environment in Receptor Assembly and Function, Annual Review of Immunology, 23, 1, 2005. Crossref

  59. Balagopalan Lakshmi, Raychaudhuri Kumarkrishna, Samelson Lawrence E., Microclusters as T Cell Signaling Hubs: Structure, Kinetics, and Regulation, Frontiers in Cell and Developmental Biology, 8, 2021. Crossref

  60. Dadsetan Sepehr, Shishkin Vyacheslav, Fomina Alla F., Intracellular Ca2+ Release Triggers Translocation of Membrane Marker FM1–43 from the Extracellular Leaflet of Plasma Membrane into Endoplasmic Reticulum in T Lymphocytes, Journal of Biological Chemistry, 280, 16, 2005. Crossref

  61. Schmitz I, Meyer C, Schulze-Osthoff K, CD95 ligand mediates T-cell receptor-induced apoptosis of a CD4+ CD8+ double positive thymic lymphoma, Oncogene, 25, 58, 2006. Crossref

  62. Patino-Lopez Genaro, Dong Xiaoyun, Ben-Aissa Khadija, Bernot Kelsie M., Itoh Takashi, Fukuda Mitsunori, Kruhlak Michael J., Samelson Lawrence E., Shaw Stephen, Rab35 and Its GAP EPI64C in T Cells Regulate Receptor Recycling and Immunological Synapse Formation, Journal of Biological Chemistry, 283, 26, 2008. Crossref

  63. Yudushkin Ivan A., Vale Ronald D., Imaging T-cell receptor activation reveals accumulation of tyrosine-phosphorylated CD3ζ in the endosomal compartment, Proceedings of the National Academy of Sciences, 107, 51, 2010. Crossref

  64. Puellmann Kerstin, Kaminski Wolfgang E., Vogel Mandy, Nebe C. Thomas, Schroeder Josef, Wolf Hans, Beham Alexander W., A variable immunoreceptor in a subpopulation of human neutrophils, Proceedings of the National Academy of Sciences, 103, 39, 2006. Crossref

  65. Sullivan Brian M., Coscoy Laurent, Downregulation of the T-Cell Receptor Complex and Impairment of T-Cell Activation by Human Herpesvirus 6 U24 Protein, Journal of Virology, 82, 2, 2008. Crossref

  66. Griessinger Christoph M., Maurer Andreas, Kesenheimer Christian, Kehlbach Rainer, Reischl Gerald, Ehrlichmann Walter, Bukala Daniel, Harant Maren, Cay Funda, Brück Jürgen, Nordin Renate, Kohlhofer Ursula, Rammensee Hans-Georg, Quintanilla-Martinez Leticia, Schaller Martin, Röcken Martin, Pichler Bernd J., Kneilling Manfred, 64 Cu antibody-targeting of the T-cell receptor and subsequent internalization enables in vivo tracking of lymphocytes by PET , Proceedings of the National Academy of Sciences, 112, 4, 2015. Crossref

  67. Balagopalan Lakshmi, Barr Valarie A., Sommers Connie L., Barda-Saad Mira, Goyal Amrita, Isakowitz Matthew S., Samelson Lawrence E., c-Cbl-Mediated Regulation of LAT-Nucleated Signaling Complexes, Molecular and Cellular Biology, 27, 24, 2007. Crossref

  68. Wolf Elmar, Gebhardt Anneli, Kawauchi Daisuke, Walz Susanne, von Eyss Björn, Wagner Nicole, Renninger Christoph, Krohne Georg, Asan Esther, Roussel Martine F., Eilers Martin, Miz1 is required to maintain autophagic flux, Nature Communications, 4, 1, 2013. Crossref

  69. Meryk Andreas, Pangrazzi Luca, Hagen Magdalena, Hatzmann Florian, Jenewein Brigitte, Jakic Bojana, Hermann-Kleiter Natascha, Baier Gottfried, Jylhävä Juulia, Hurme Mikko, Trieb Klemens, Grubeck-Loebenstein Beatrix, Fcμ receptor as a Costimulatory Molecule for T Cells, Cell Reports, 26, 10, 2019. Crossref

  70. Cassioli Chiara, Patrussi Laura, Valitutti Salvatore, Baldari Cosima T., Learning from TCR Signaling and Immunological Synapse Assembly to Build New Chimeric Antigen Receptors (CARs), International Journal of Molecular Sciences, 23, 22, 2022. Crossref

  71. Jin Yan, Deng Zhifeng, Zhu Ting, Membrane protein trafficking in the anti-tumor immune response: work of endosomal-lysosomal system, Cancer Cell International, 22, 1, 2022. Crossref

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