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Critical Reviews™ in Immunology

ISSN for PRINT: 1040-8401

Institutional price:	$831.00
Issues per year:	6

Best Paper Award Selection - Editorial Board Site

2004, Volume24

92 pages

DOI: 10.1615/CritRevImmunol.v24.i5

Issue price - $132.00

Role of the D Prostanoid Receptor 1 in the Modulation of Immune and Inflammatory Responses

Francois Trottein
Centre d'Immunologie et de Biologie Parasitaire, Institut National de la Sante et de la Recherche Medicale U547, Institut Pasteur de Lille, 59019 Lille cedex, France

Christelle Faveeuw
Centre d'Immunologie et de Biologie Parasitaire, Institut National de la Sante et de la Recherche Medicale U547, Institut Pasteur de Lille, 59019 Lille cedex, France

Philippe Gosset
Institut National de la Sante et dela Recherche Medicale U416, Institut Pasteur de Lille, 59019, Lille cedex, France

Veronique Angeli
Centre d’Immunologie et de Biologie Parasitaire,Institut National de la Sante et de la Recherche Medicale U547,Institut Pasteur de Lille,59019 Lille cedex, France; Department of Gene and Cell Medicine,Mount Sinai School of Medicine,New York, NY 10029

ABSTRACT

Prostaglandins (PGs) are potent eicosanoid lipid mediators derived from phospholipase-released arachidonic acid, which are involved in numerous homeostatic biological functions and inflammation. They are generated by the sequential action of cyclooxygenase isozymes and cell-specific PG synthases. Along with their role in inflammatory responses, recent accumulating evidence strongly suggests that PGs, including PGD₂, are part of a complex regulatory network that modulates the immune system. PGD₂ is the major prostanoid secreted by activated mast cells and has long been implicated in allergic diseases. The aim of this review is to discuss our current understanding of the mode of action of PGD₂ during Th2-mediated inflammation. We also discuss recent findings, which suggest that PGD₂ exerts important effects on both immune and inflammatory responses by targeting the D prostanoid receptor 1 on dendritic cells, the most potent antigen-presenting cells.