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Critical Reviews™ in Immunology

Published 6 issues per year

ISSN Print: 1040-8401

ISSN Online: 2162-6472

The Impact Factor measures the average number of citations received in a particular year by papers published in the journal during the two preceding years. 2017 Journal Citation Reports (Clarivate Analytics, 2018) IF: 1.3 To calculate the five year Impact Factor, citations are counted in 2017 to the previous five years and divided by the source items published in the previous five years. 2017 Journal Citation Reports (Clarivate Analytics, 2018) 5-Year IF: 2.6 The Eigenfactor score, developed by Jevin West and Carl Bergstrom at the University of Washington, is a rating of the total importance of a scientific journal. Journals are rated according to the number of incoming citations, with citations from highly ranked journals weighted to make a larger contribution to the eigenfactor than those from poorly ranked journals. Eigenfactor: 0.00079 The Journal Citation Indicator (JCI) is a single measurement of the field-normalized citation impact of journals in the Web of Science Core Collection across disciplines. The key words here are that the metric is normalized and cross-disciplinary. JCI: 0.24 SJR: 0.429 SNIP: 0.287 CiteScore™:: 2.7 H-Index: 81

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Role of Type II NKT Cells in the Suppression of Graft-versus-Host Disease

Volume 28, Issue 3, 2008, pp. 249-267
DOI: 10.1615/CritRevImmunol.v28.i3.50
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ABSTRACT

Natural killer T (NKT) cells, a distinct subset of T cells that recognize glycolipids on CD1d molecules, express both TCR and NK receptors and are critical in regulating various immune responses by modulating the Th1/Th2 balance. Upon activation, NKT cells produce large amounts of IL-4 and IFN-γ, resulting in the enhancement or inhibition of immune responses. Recent studies have shown that NKT cells are heterogeneous in terms of the expression of a specific Vα chain of TCR (Vα14-Jα18 in mice and Vα24-JαQ in humans) and reactivity against the glycolipid α-galactosylceramide (α-GalCer). Accordingly, NKT cells are classified into type I (invariant) and type II (non-invariant) cells in mice and humans. Although the functional roles of type I NKT cells are well characterized in various immune diseases, little is known regarding the function of type II NKT cells. Recent study has demonstrated that type II NKT cells in donor bone marrow play protective roles in graft-versus-host disease (GVHD), in which the complicated immunologic processes are involved. In this review, we discuss the pathogenesis of GVHD and the distinct functions of type II NKT cells in the development of GVHD.

CITED BY
  1. Morecki Shoshana, Slavin Shimon, Immunoregulation of GVHD by triggering the innate immune system with CpG, Expert Review of Hematology, 2, 4, 2009. Crossref

  2. Yang Jie, Gao Li, Liu Yan, Ren Yana, Xie Rufeng, Fan Huahua, Qian Kaicheng, Adoptive therapy by transfusing expanded donor murine natural killer T cells can suppress acute graft-versus-host disease in allogeneic bone marrow transplantation, Transfusion, 50, 2, 2010. Crossref

  3. Hung Jung-Tung, Huang Jing-Rong, Yu Alice L., Tailored design of NKT-stimulatory glycolipids for polarization of immune responses, Journal of Biomedical Science, 24, 1, 2017. Crossref

  4. Raza Ali, Vierling John M., Graft-Versus-Host Disease, in Liver Immunology, 2014. Crossref

  5. Lev A, Amariglio N, Spirer Z, Katz U, Bielorai B, Rechavi G, Somech R, Specific self-antigen-driven immune response in pericardial effusion as an isolated GVHD manifestation, Bone Marrow Transplantation, 45, 6, 2010. Crossref

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