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Critical Reviews™ in Immunology

ISSN for PRINT: 1040-8401

Institutional price:	$831.00
Issues per year:	6

Best Paper Award Selection - Editorial Board Site

2007, Volume27

82 pages

Issue price - $153.00

Comprehensive Insight into Human Aminoacyl-tRNA Synthetases as Autoantigens in Idiopathic Inflammatory Myopathies

Miroslawa Jura
Institute of Bioorganic Chemistry of Polish Academy of Sciences, 60-704 Poznan, Poland; and BioInfoBank Institute, ul. Limanowskiego 24A, 60-744 Poznan, Poland

Leszek Rychlewski
BioInfoBank Institute, ul. Limanowskiego 24A, 60-744 Poznan, Poland

Jan Barciszewski
Institute of Bioorganic Chemistry of Polish Academy of Sciences, 60-704 Poznan, Poland

ABSTRACT

Autoantibodies against aminoacyl-tRNA synthetases (anti-AARS) belong to the group of the myositis specific autoantibodies (MSAs). Their association with the onset and development of the idiopathic inflammatory myopathies (IIM) implies their participation in the pathogenesis of the diseases. Since the appearing of anti-Jo-1 and other anti-AARSs is related to characteristic immunogenetic and clinical features, they can be considered specific markers in diagnosis and classification of patients affected by IIM. Here, we present an overview of anti-AARSs, their chemoattractant properties, their detection methods, genetic risks, and protective factors.