Critical Reviews™ in Immunology

ISSN for PRINT: 1040-8401

For Online Access

Best Paper Award Selection - Editorial Board Site

2007, Volume27

Issue 6

82 pages

Issue price - $153.00

Anna Vecchiarelli
Microbiology Section, Department of Experimental Medicine and Biochemical Sciences, University of Perugia, Perugia, Italy

Many capsular polysaccharide antigens are generally considered to be classic T-cell independent antigens that stimulate humoral response. This response is poor and short lived due to the absence of T-cell involvement. Recent emerging evidence suggests that fungal capsular polysaccharides may negatively affect T-cell response. This effect is indirectly mediated by antigen-presenting cells that sense microbial polysaccharides and manage T-cell response. This review will revisit the role of the cryptococcal capsular polysaccharide as a nonconventional regulator of natural and adaptive immune response, revealing the hidden nature of its poor immunogenicity and novel opportunities for the biomedical exploitation of this nontoxic compound.

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