Critical Reviews™ in Immunology

ISSN for PRINT: 1040-8401

For Online Access

Best Paper Award Selection - Editorial Board Site

2003, Volume23

Randy R. Brutkiewicz
Department of Microbiology and Immunology, Indiana University School of Medicine, The Walther Oncology Center, Building R2, Room 302, 950 W. Walnut St., Indianapolis, IN 46202-5181

Yinling Lin
Department of Microbiology and Immunology, Indiana University School of Medicine, and The Walther Oncology Center, Indianapolis, IN 46202; and The Walther Cancer Institute, Indianapolis, IN 46208

Sungyoo Cho
Department of Microbiology and Immunology, Indiana University School of Medicine, and The Walther Oncology Center, Indianapolis, IN 46202; and The Walther Cancer Institute, Indianapolis, IN 46208

Yu Kyeong Hwang
Department of Microbiology and Immunology, Indiana University School of Medicine, and The Walther Oncology Center, Indianapolis, IN 46202; and The Walther Cancer Institute, Indianapolis, IN 46208

Venkataraman Sriram
Department of Microbiology and Immunology, Indiana University School of Medicine, and The Walther Oncology Center, Indianapolis, IN 46202; and The Walther Cancer Institute, Indianapolis, IN 46208

Tonya J. Roberts
Department of Microbiology and Immunology, Indiana University School of Medicine, and The Walther Oncology Center, Indianapolis, IN 46202; and The Walther Cancer Institute, Indianapolis, IN 46208

CD1d molecules are lipid antigen-presenting molecules. They are involved in presenting these antigens to a unique subpopulation of T cells called natural killer T (NKT) cells, which have the capacity to produce both T helper (Th) 1 and Th2 cytokines. Thus, it is possible that the antigens presented by CD1d and/or the level at which they are presented could have profound effects on the immunoregulation of autoimmune and infectious diseases, as well as cancer. Because of the ability of CD1d-binding ligands to modulate NKT cell responses, targeting CD1d-mediated antigen presentation as a novel approach for new therapies in these and other diseases holds great promise.

DOI: 10.1615/CritRevImmunol.v23.i56.30 Download article, 18 pages

Article price - $35.00

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