Critical Reviews™ in Immunology

ISSN for PRINT: 1040-8401

For Online Access

Best Paper Award Selection - Editorial Board Site

2007, Volume27

Issue 3

77 pages

Issue price - $153.00

Anastas Pashov
University of Arkansas for Medical Sciences, Little Rock, AR, USA

Behjatolah Monzavi-Karbassi
University of Arkansas for Medical Sciences, Little Rock, AR, USA

Gajendra Raghava
University of Arkansas for Medical Sciences, Little Rock, AR, USA

Thomas Kieber-Emmons
University of Arkansas for Medical Sciences, Little Rock, AR, USA

Mechanisms of broad cross-protection, as seen in viral infection and also applied to vaccines, emphasize preexisting antibodies, CD8+ memory T cells, and accelerated B-cell responses reactive with conserved regions in antigens. Another practical application to induce broad-spectrum responses is making use of multispecific antigen recognition by antibodies and T cells. Antibody polyreactivity can be related to the capacity of the antigen-combining site to accommodate a number of different small epitopes or to attain different conformations. A better understanding of the functionality of molecular interactions with graded specificity might help the design of polyreactive immunogens inducing antibody responses to a predefined set of target antigens. We have found this approach useful in targeting tumor-associated carbohydrate antigens in cancer vaccine development. Using combinatorial libraries and pharmacophore design principles, carbohydrate mimetic peptides were created that not only induce antibodies with multiple specificities, but also cellular responses that inhibit tumor growth in vivo.

Download article, 247-270 pages

Article price - $50.00

<< Previous article   Next article >>