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Critical Reviews™ in Immunology

ISSN for PRINT: 1040-8401

Institutional price:	$831.00
Issues per year:	6

Best Paper Award Selection - Editorial Board Site

2000, Volume20

96 pages

Issue price - $132.00

CD5 Signal Transduction: Positive or Negative Modulation of Antigen Receptor Signaling

Francisco Lozano
Servei d’Immunologia, ICII, D'Investigacions Biomediques August Pi i Sunyer (IDIBAPS), Hospital Clinic; and Unitat d’Immunologia, Dept. de Biologia Cellular i Anatomia Patologica, Facultat de Medicina, Universitat de Barcelona, Barcelona, Spain

Maria Simarro
Servei d'lmmunologia, Institut D'Investigacions Biomediques August Pi i Sunyer (IDIBAPS), Hospital Clinic, Villarroel 170, 08036 Barcelona, Spain

Javier Calvo
Servei d'lmmunologia, Institut D'Investigacions Biomediques August Pi i Sunyer (IDIBAPS), Hospital Clinic, Villarroel 170, 08036 Barcelona, Spain

Josep M. Vila
Servei d'lmmunologia, Institut D'Investigacions Biomediques August Pi i Sunyer (IDIBAPS), Hospital Clinic, Villarroel 170, 08036 Barcelona, Spain

Olga Padilla
Servei d’Immunologia, Institut Clinic d’Infeccions i Immunologia (ICII), Institut d’Investigacions Biomediques August Pi i Sunyer (IDIBAPS), Hospital Clinic, Barcelona, Spain

Michael A. Bowen
Immunology and Inflammation Department, Bristol Myers-Squibb Pharmaceutical Research Institute, Princeton, New Jersey

Kerry S. Campbell
Fox Chase Cancer Center, Institute for Cancer Research, Division of Basic Science, Philadelphia, Pennsylvania

ABSTRACT

The CD5 lymphocyte surface glycoprotein is a coreceptor involved in the modulation of antigen-specific receptor-mediated activation and differentiation signals. Although first considered a costimulatory molecule in mature peripheral T cells, recent studies of CD5^−/− mice have opened the possibility that CD5 may also mediate inhibitory signals that attenuate TCR/CD3- and BCR-mediated triggering in thymocytes and a subgroup of B cells (B-1a cells), respectively. The ultimate molecular basis for these differential modulatory properties of CD5, depending on the context of lymphocyte subset and differentiation stage, are presently unknown and are an issue of current intensive investigation. Here, we review recent reports, both contradictory and complementary, focused on CD5-mediated molecular intracellular signaling events that could provide the basis for its immunomodulatory properties.