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Critical Reviews™ in Immunology

ISSN for PRINT: 1040-8401

Institutional price:	$831.00
Issues per year:	6

Best Paper Award Selection - Editorial Board Site

2005, Volume25

80 pages

DOI: 10.1615/CritRevImmunol.v25.i5

Issue price - $132.00

Molecular Interactions Between Dendritic Cells and Salmonella: Escape from Adaptive Immunity and Implications on Pathogenesis

Susan M. Bueno
Departamento de Genetica Molecular y Microbiologia, Facultad de Ciencias Biologicas

Jaime A. Tobar
Departamento de Genetica Molecular y Microbiologia, Facultad de Ciencias Biologicas

Mirentxu I. Iruretagoyena
Departamento de Genetica Molecular y Microbiologia, Facultad de Ciencias Biologicas

Alexis M. Kalergis
Departamento de Genetica Molecular y Microbiologia, Facultad de Ciencias Biologicas; Departamento de Reumatologia, Facultad de Medicina, Pontificia Universidad Catolica de Chile; Department of Microbiology and Immunology, Albert Einstein College

ABSTRACT

Dendritic cells (DCs) constitute the link between innate and adaptive immunity by directly recognizing pathogen-associated molecular patterns (PAMPs) on bacteria and by processing and presenting bacterial antigens to T cells. Recognition of PAMPs renders DCs as professional antigen-presenting cells with the ability to prime naive T cells and to initiate the adaptive immune response against pathogen-derived antigens. For this reason, any interference with DC function might be advantageous for bacterial survival and dissemination. Identification of the molecular interactions occurring between DCs and bacterial pathogens is necessary to understand the mechanisms that virulent bacteria have evolved to prevent recognition by the adaptive immune system. This could be helpful in the identification of possible new targets that might lead to the design of effective therapies aimed at preventing or treating serious infections by these pathogens. In this article, we focus on Salmonella enterica serovar Typhimurium, the causative agent of typhoid-like disease in the mouse, and how it is able to escape from DC-mediated antigen presentation by avoiding lysosomal degradation. This feature of virulent Salmonella requires the functional expression of the Type Three Secretion System (TTSS) and effector proteins encoded within the Salmonella pathogenicity island 2 (SPI-2). Recent studies have demonstrated that impairment of DC function by the activity of SPI-2 gene products is crucial for Salmonella pathogenesis.