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Critical Reviews™ in Immunology

ISSN for PRINT: 1040-8401

Institutional price:	$831.00
Issues per year:	6

Best Paper Award Selection - Editorial Board Site

2002, Volume22

66 pages

Issue price - $132.00

Autoimmunity to Glutamate Receptors in the Central Nervous System

Lorise C. Gahring
Salt Lake City VA-GRECC and University of Utah School of Medicine, Departments of Internal Medicine and Neurobiology and Anatomy, 2C110, 50 North Medical Drive, Salt Lake City, UT 84132

Scott W. Rogers
Salt Lake City VA-GRECC and University of Utah School of Medicine, Departments of Internal Medicine and Neurobiology and Anatomy, 2C110, 50 North Medical Drive, Salt Lake City, UT 84132

ABSTRACT

Autoimmunity to glutamate receptors (GluR) of the central nervous system offers an attractive model to begin the experimental dissection of the etiology of immune-related neurodegenerative diseases. Here we discuss the known mechanisms of generating autoimmunity to different members of the GluR neurotransmitter receptor family within the unique environment of the brain and how autoantibody-receptor interactions contribute to abnormal neurotransmission and eventually pathology.