Critical Reviews™ in Immunology

ISSN for PRINT: 1040-8401

For Online Access

Best Paper Award Selection - Editorial Board Site

2005, Volume25

Issue 1

78 pages

DOI: 10.1615/CritRevImmunol.v25.i1

Issue price - $132.00

Leslie L. Sharp
The Scripps Research Institute, 10550 North Torrey Pines Rd., La Jolla, California 92037

Julie M. Jameson
The Scripps Research Institute, 10550 North Torrey Pines Rd., La Jolla, California 92037

Deborah A. Witherden
The Scripps Research Institute, 10550 North Torrey Pines Rd., La Jolla, California 92037

H. Kiyomi Komori
The Scripps Research Institute, 10550 North Torrey Pines Rd., La Jolla, California 92037

Wendy L. Havran
The Scripps Research Institute, 10550 North Torrey Pines Rd., La Jolla, California 92037

Although γδ T cells compose a small proportion of lymphocytes in lymphoid compartments and peripheral blood, they are the major T-cell population present in epithelial tissues. However, the role played by γδ TCR expressing intraepithelial lymphocytes (IEL) has been enigmatic. The location of tissue-resident IEL suggests that they are important members of the first line of defense against insult for organs exposed to the environment, including the skin, gut, lungs, and reproductive system. Dendritic epidermal T cells (DETC) are the skin-resident γδIEL and serve as a model system for γδIEL in other locations. DETC have demonstrated importance in the modulation of immune responses, surveillance and repair of tissue, and resistance to infection. This work discusses recent developments in understanding DETC activation.

DOI: 10.1615/CritRevImmunol.v25.i1.10 Download article, 1-18 pages

Article price - $35.00

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