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Critical Reviews™ in Therapeutic Drug Carrier Systems

ISSN for PRINT: 0743-4863

Institutional price:	$1014.00
Issues per year:	6

Best Paper Award Selection - Editorial Board Site

2004, Volume21

132 pages

DOI: 10.1615/CritRevTherDrugCarrierSyst.v21.i3

Issue price - $161.00

Mucosal Drug Delivery: Membranes, Methodologies, and Applications

Yifan Song
Department of Pharmacology and Physiology, University of Medicine and Dentistry of New Jersey, Lab for Drug Delivery, Newark, New Jersey, USA

Yiping Wang
Ernest Mario School of Pharmacy, Rutgers University, Piscataway, New Jersey, USA

Rashmi Thakur
Ernest Mario School of Pharmacy, Rutgers University, Piscataway, New Jersey, USA

Victor M. Meidan
Department of Pharmaceutical Sciences, University of Strathclyde, Glasgow, Scotland UK

Bozena Michniak
Department of Pharmacology and Physiology, University of Medicine and Dentistry of New Jersey, Lab for Drug Delivery, Newark, New Jersey; University of South Carolina, Basic Pharmaceutical Sciences, 700 Sumter St., Columbia, SC 29208, USA

ABSTRACT

In recent years, extensive research into novel forms of drug delivery has suggested that mucosal approaches offer a promising therapeutic alternative, especially for systemically acting drugs. Transmucosal drug delivery offers many benefits, including noninvasive administration, convenience, rapid onset, as well as elimination of hepatic first-pass metabolism. The investigated absorptive surfaces consist of the nasal, buccal, ocular, vaginal, and rectal mucosae. Among these, the nasal and buccal routes have proved the most promising to date. The bioavailability achieved mainly depends upon the pathophysiological state of the mucosa and the properties of both the drug and delivery systems. Various agents can increase the efficacy of transmucosal drug delivery. These include cyclodextrins, bile salts, surfactants, fusidic acid derivatives, microspheres, liposomes, and bioadhesive agents.The mechanisms of action, effectiveness, and toxicity profiles of these enhancers have been investigated extensively in both animal and human models.