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ISSN: 0743-4863 Print
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DOI: 10.1615/CritRevTherDrugCarrierSyst.v20.i6
Pages: 106
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DOI: 10.1615/CritRevTherDrugCarrierSyst.v20.i6.10
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Article price - $40.00 |
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Remote Controlled Capsules in Human Drug Absorption (HDA) Studies
Ian R. Wilding, PhD
Pharmaceutical Profiles Ltd., Ruddington Fields, Ruddington, Nottingham, UK, NG11 6JS
David V. Prior, PhD
Pharmaceutical Profiles Ltd., Ruddington Fields, Ruddington, Nottingham, UK
ABSTRACT
The biopharmaceutical complexity of today's new drug candidates provides significant challenges for pharmaceutical scientists in terms of both candidate selection and optimizing subsequent development strategy. In addition, life cycle management of marketed drugs has become an important income stream for pharmaceutical companies, but the selection of least risk/highest benefit strategies is far from simple. The proactive adoption of human drug absorption (HDA) studies using remote controlled capsules offers the pharmaceutical scientist significant guidance for planning a route through the maze of product development. This review examines the position of HDA studies in drug development, using a variety of case histories and an insightful update on remote controlled capsules to achieve site-specific delivery.
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