Critical Reviews™ in Therapeutic Drug Carrier Systems

ISSN for PRINT: 0743-4863

For Online Access

Best Paper Award Selection - Editorial Board Site

2008, Volume25

Issue 5

83 pages

Issue price - $203.00

Tarun Goswami
Thomas J. Long School of Pharmacy and Health Sciences, University of the Pacific, Stockton, CA 95211

Bhaskara R. Jasti
Thomas J. Long School of Pharmacy and Health Sciences, University of the Pacific, Stockton, CA 95211

Xiaoling Li
Thomas J. Long School of Pharmacy and Health Sciences, University of the Pacific, Stockton, CA 95211

The sublingual route is one of the early modes of administration for systemic drug delivery. This route avoids first-pass metabolism and affords quick drug entry into the systemic circulation. Attempts have been made to deliver various pharmacologically active agents, such as cardiovascular drugs, analgesics, and peptides, across the sublingual mucosa. In this review, the anatomical structure, blood supply, biochemical composition, transport pathways, permeation enhancement strategies, in vitro / in vivo models, and clinical investigations for the sublingual route of drug delivery is discussed.

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