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Hydrobiological Journal

ISSN for PRINT: 0018-8166

Institutional price:	$1994.00
Issues per year:	6

Best Paper Award Selection - Editorial Board Site

2000, Volume36

146 pages

Issue price - $369.00

Natural Populations of Blue-green Algae as Producers of Biologically Active Substances (BAS)

Yu. A. Kirpenko
Institute of Hydrobiology, National Academy of Sciences of Ukraine; Institute of Pharmacology and Toxicology, Academy of Medical Sciences, Kiev, Ukraine

N. I. Kirpenko
Institute of Hydrobiology, National Academy of Sciences of Ukraine, Kiev, Ukraine

A. V. Parshikov
Institute of Hydrobiology, National Academy of Sciences of Ukraine; Institute of Pharmacology and Toxicology, Academy of Medical Sciences, Kiev, Ukraine

ABSTRACT

The biological active substance from the biomass of natural populations of Cyanophyta with predominance of Microcystis aeruginosa Kuetz. emend. Elenk. characterized by high vitality has been obtained. It was further refined and separated into 5 fractions with their molecular weight [measured in a.m.u. (atomic mass unit) or Dalton) varying from 15 to 70 kDa. The chemical nature and original structure of these substances have been determined. The critical toxicity level of the substances has been estimated using peroral, peritoneal and intracerebral ways of introduction into an organism. It has been shown that the biological active substance is characterized by cardiotropic, neurotropic, cytotoxic, antiturnoural, antimicrobial effects, which makes it possible to plan its therapeutic use.