Critical Reviews™ in Oncogenesis

ISSN for PRINT: 0893-9675

For Online Access

Best Paper Award Selection - Editorial Board Site

2006, Volume12

Patricia Mesquita
IPATIMUP, Institute of Molecular Pathology and Immunology of the University of Porto, and the Medical Faculty of the University of Porto, Rua Dr. Roberto Frias s/n, 4200 Porto, Portugal

Raquel Almeida
Institute of Molecular Pathology and Immunology (IPATIMUP), University of Porto, Rua Dr. Roberto Frias s/n, 4200 Porto, Portugal

Nuno Lunet
Department of Hygiene and Epidemiology, Medical Faculty, University of Porto, 4200 Porto, Portugal

Celso A. Reis
Institute of Molecular Pathology and Immunology (IPATIMUP), University of Porto, Rua Dr. Roberto Frias s/n, 4200 Porto, Portugal

Luis Filipe Santos Silva
Institute of Molecular Pathology and Immunology (IPATIMUP), University of Porto, Rua Dr. Roberto Frias s/n, 4200 Porto, Portugal

Jacinta Serpa
Institute of Molecular Pathology and Immunology (IPATIMUP), University of Porto, Rua Dr. Roberto Frias s/n, 4200 Porto, Portugal

Isabelle Van Seuningen
Unite INSERM 560, Place de Verdun, 59045 Lille Cedex, France

Henrique Barros
Department of Hygiene and Epidemiology, Medical Faculty, University of Porto, 4200 Porto, Portugal

Leonor David
Institute of Molecular Pathology and Immunology (IPATIMUP), Medical Faculty, University of Porto, Rua Dr. Roberto Frias s/n, 4200 Porto, Portugal

Metaplasia, in general, and intestinal metaplasia, in particular, are transdifferentiation processes triggered by environmental aggressions. The heterogeneity of different morphologic variants of metaplasia and distinction from close morphologic entities—heterotopia and hamartoma—is reviewed. Recent data on the characterization of the molecular and epidemiological data involved in the development and progression of lesions of gastric intestinal metaplasia are discussed. A redefinition of intestinal metaplasia is proposed.

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