Critical Reviews™ in Oncogenesis

ISSN for PRINT: 0893-9675

For Online Access

Best Paper Award Selection - Editorial Board Site

2000, Volume11

Issue 1

102 pages

Issue price - $100.00

Marco W. J. Schreurs
Departments of Tumor Immunology and Medical Oncology, University Hospital Nijmegen St. Radboud, Philips van Leydenlaan 25, 6525 EX Nijmegen, The Netherlands

Andreas A. O. Eggert
Departments of Tumor Immunology and Medical Oncology, University Hospital Nijmegen St. Radboud, Philips van Leydenlaan 25, 6525 EX Nijmegen, The Netherlands

Cornells J. A. Punt
Departments of Tumor Immunology and Medical Oncology, University Hospital Nijmegen St. Radboud, Philips van Leydenlaan 25, 6525 EX Nijmegen, The Netherlands

Carl G. Figdor
Departments of Tumor Immunology and Medical Oncology, University Hospital Nijmegen St. Radboud, Philips van Leydenlaan 25, 6525 EX Nijmegen, The Netherlands

Gosse J. Adema
Departments of Tumor Immunology and Medical Oncology, University Hospital Nijmegen St. Radboud, Philips van Leydenlaan 25, 6525 EX Nijmegen, The Netherlands

B and T lymphocytes are the effectors of specific immunity. However, their function is critically dependent on dendritic cells (DC). DC are professional antigen presenting cells that both initiate and modulate the immune response. The recent breakthrough in the generation of DC from their progenitors has stimulated research on DC in both fundamental and clinical immunology. Objective immune response induction has now been reported in clinical studies using DC. In this review we discuss the development and potential of DC-based vaccines to induce antitumor immunity.

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