Critical Reviews™ in Biomedical Engineering

ISSN for PRINT: 0278-940X

For Online Access

Best Paper Award Selection - Editorial Board Site

2002, Volume30

Issue 4-6

272 pages

DOI: 10.1615/CritRevBiomedEng.v30.i456

Issue price - $798.00

Cameron C. McIntyre
Department of Biomedical Engineering, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA

Nitish V. Thakor
Johns Hopkins University School of Medicine, Department of Biomedical Engineering, Traylor Research Building, Room 701, 720 Rutland Ave., Baltimore MD, 21205

High-frequency deep brain stimulation (DBS) of the thalamus or basal ganglia represents an effective clinical technique for the treatment of several medically refractory movement disorders, including Parkinson's disease. However, understanding of the mechanisms of action of DBS remains elusive. The goal of this review is to address our understanding of the effects of high-frequency stimulation within the central nervous system based on results from functional imaging, neural recording, and neural modeling experiments. Using these results, we address the main hypotheses on the mechanisms of action of DBS and conclude that stimulation-induced desynchronization of network oscillations represents the hypothesis that best explains the presently available data.

DOI: 10.1615/CritRevBiomedEng.v30.i456.20 Download article, 33 pages

Article price - $70.00

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