Critical Reviews™ in Eukaryotic Gene Expression

ISSN for PRINT: 1045-4403

For Online Access

Best Paper Award Selection - Editorial Board Site

2005, Volume15

Issue 4

90 pages

Issue price - $169.00

Nadir M. Maraldi
ITOI-CNR, Unit of Bologna, c /o IOR, Via di Barbiano 1/10; Laboratory of Biologia Cellulare e Microscopia Elettronica, IOR; and Department of Scienze Anatomiche Umane e Fisiopatologia Apparato Locomotore, University of Bologna, Italy

Giovanna Lattanzi
ITOI-CNR, Unit of Bologna, c /o IOR, Via di Barbiano 1/10, Bologna, Italy

Two major events are emerging as being involved in the fine regulatory mechanisms that control gene expression through the nuclear envelope/lamina. The first is the linkage of envelope proteins to transcription factors, most of which function as transcriptional repressors. The second is the interplay between nuclear lamina/nuclear envelope proteins and chromatin, through more or less direct interactions with DNA-binding proteins. The first mechanism appears to play a major role in tissue-specific functions, whereas the latter mechanism likely modifies higher-order chromatin organization, thus regulating differentiation and aging. This review highlights the importance of the study of a group of genetic diseases, collectively referred to as laminopathies, to understand the actual role played by lamins in ensuring the fidelity of gene expression and in modulating cеll differentiation.

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