Critical Reviews™ in Eukaryotic Gene Expression

ISSN for PRINT: 1045-4403

For Online Access

Best Paper Award Selection - Editorial Board Site

2003, Volume13

Issue 2-4

227 pages

DOI: 10.1615/CritRevEukaryotGeneExpr.v13.i24

Issue price - $507.00

Adele Boskey
Starr Chair in Mineralized Tissue Research, Hospital for Special Surgery, 535 East 70th Street, New York, NY 10021

Bones of animal models of osteopetrosis in a variety of animal species are characterized by increased density but impaired mechanical properties. Analysis of mineral properties by several physical-chemistry techniques has shown that the crystals in the hyper-mineralized bones are smaller and less perfect than those in age-matched normal animals. Here we review the data on mineral crystal changes in osteopetrosis and the techniques for determining these properties, and suggest that the small crystal size contributes to the bones’ altered mechanical properties.

DOI: 10.1615/CritRevEukaryotGeneExpr.v13.i24.50 Download article, 8 pages

Article price - $35.00

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