ITEMS

modern scholarly publishers in the finest tradition

Journals

	Search

Critical Reviews™ in Eukaryotic Gene Expression

ISSN for PRINT: 1045-4403

Institutional price:	$708.00
Issues per year:	4

Best Paper Award Selection - Editorial Board Site

2008, Volume18

82 pages

Issue price - $212.00

Vitamin D Control of Gene Expression: Temporal and Spatial Parameters for Organization of the Regulatory Machinery

Martin Montecino
Laboratory of Cellular and Molecular Biology, Department of Biochemistry and Molecular Biology, Faculty of Biological Sciences, University of Concepcion, Casilla 160-C, Concepcion, Chile

Gary Stein
UMASS

Janet L. Stein
Department of Cell Biology and Cancer Center, University of Massachusetts Medical School, Worcester, MA 01655

Jane B. Lian
Department of Cell Biology and Cancer Center, University of Massachusetts Medical School, 55 Lake Avenue North, Worcester, MA 01655

Andre J. van Wijnen
Department of Cell Biology and Cancer Center, University of Massachusetts Medical School, Worcester, MA 01655

Loreto Carvallo
Departamento de Bioquímicay Biología Molecular, Facultad de Ciencias Biolêgicas, Universidad de Concepción, Concepción, Chile

Sylvain Marcellini
Departamento de Bioquímicay Biología Molecular, Facultad de Ciencias Biolêgicas, Universidad de Concepción, Concepción, Chile

Fernando Cruzat
Departamento de Bioquímicay Biología Molecular, Facultad de Ciencias Biolêgicas, Universidad de Concepción, Concepción, Chile

Gloria Arriagada
Departamento de Bioquímicay Biología Molecular, Facultad de Ciencias Biolêgicas, Universidad de Concepción, Concepción, Chile

ABSTRACT

Vitamin D is a principal modulator of skeletal gene expression, thus necessitating an understanding of interfaces between the activity of this steroid hormone and regulatory cascades that are functionally linked to the regulation of skeletal genes. Physiologic responsiveness requires combinatorial control, whereas coregulatory proteins determine the specificity of biologic responsiveness to physiologic cues. It is becoming increasingly evident that regulatory complexes containing the vitamin D receptor are dynamic rather than static. Temporal and spatial modifications in the composition of these complexes provide a mechanism for integrating regulatory signals to support positive or negative control through synergism and antagonism. Compartmentalization of components of vitamin D control in nuclear microenvironments supports the integration of regulatory activities, perhaps by establishing thresholds for protein activity in time frames that are consistent with the execution of regulatory signaling.