Critical Reviews™ in Eukaryotic Gene Expression

ISSN for PRINT: 1045-4403

For Online Access

Best Paper Award Selection - Editorial Board Site

2006, Volume16

Issue 2

94 pages

Issue price - $169.00

Donald H. Rubin
Research Medicine, Veterans Affairs Tennessee Valley Healthcare System, Nashville, TN 37212; Department of Medicine, Division of Infectious Diseases; and Department of Microbiology and Immunology, Vanderbilt University, Nashville, TN 37232

H. Earl Ruley
Department of Microbiology and Immunology, Vanderbilt University, Nashville, TN 37232

Viruses are obligate intracellular parasites that rely upon the host cell for activities essential to their life cycles. Gene-trap mutagenesis provides a rapid, genome-wide strategy to identify candidate cellular genes required for virus replication. The candidate genes provide a starting point for mechanistic studies of cellular processes that participate in the virus life cycle and may provide targets for novel antiviral therapies.

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