Critical Reviews™ in Eukaryotic Gene Expression

ISSN for PRINT: 1045-4403

For Online Access

Best Paper Award Selection - Editorial Board Site

2000, Volume10

Issue 1

118 pages

Issue price - $169.00

Jurgen Bode
GBF, National Center for Biotechnologioal Research, D-38124 Braunschweig, Mascheroder Weg 1

Craig Benham
Department of Biomathematical Sciences, Box 1023, Mount Sinai School of Medicine, 1 Gustave Levy Place, New York, NY 10029

Angela Knopp
GBF, National Center for Biotechnologioal Research, D-38124 Braunschweig, Mascheroder Weg 1

Christian Mielke
University of Aarhus, Dept. of Molecular and Structural Biology, C.F. Mollers Alle 131, DK-8000 Aarhus C, Denmark

For a long time S/MARs could only be characterized by the assays in vitro that led to their detection. Only recently a number of biological activities emerged that are common to most or all S/MARs that are detected by the classic procedures. This review focuses on the phenomenon of transcriptional augmentation that is found for genomically anchored or episomal genes and on a group of partially overlapping activities that are suited to maintain an episomal status. Further, it is attempted to correlate properties of the S/MAR-scaffold interaction with prominent or prototype protein binding partners.

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