Critical Reviews™ in Eukaryotic Gene Expression

ISSN for PRINT: 1045-4403

For Online Access

Best Paper Award Selection - Editorial Board Site

2004, Volume14

Issue 1&2

151 pages

DOI: 10.1615/CritRevEukaryotGeneExpr.v14.i12

Issue price - $338.00

Sergey V. Razin
Laboratory of Structural and Functional Organization of hromosomes, Institute of Gene Biology of the Russian Academy of Sciences, Vavilov Str. 34/5, 117334 Moscow, Russia

Andrei Petrov
Department of Chemistry, Moscow State University; and CNRS UMR-8126, Institut Gustave Roussy, Villejuif 94805, France

Alan Hair
CNRS UMR-8126, Institut Gustave Roussy, Villejuif 94805, France

Yegor S. Vassetzky
CNRS UMR-8126, Institut Gustave Roussy, Villejuif 94805, France

The nucleus is a highly organized solid-state system, rigid and flexible at the same time, where enzymes are organized in complex processing factories. This is achieved by the organization of nuclear DNA into territories and domains, which allow compartmentalization and compaction without sacrificing accessibility. The present review discusses the implications of the organization of chromosomal domains and territories in development and carcinogenesis.

DOI: 10.1615/CritRevEukaryotGeneExpr.v14.i12.50 Download article, 10 pages

Article price - $35.00

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