Published 6 issues per year
ISSN Print: 1045-4403
ISSN Online: 2162-6502
Indexed in
Recent Advances in the Use of Serological Bone Formation Markers to Monitor Callus Development and Fracture Healing
ABSTRACT
The failure of an osseous fracture to heal, or the development of a nonunion, is common; however, current diagnostic measures lack the capability of early and reliable detection of such events. Analyses of radiographic imaging and clinical examination, in combination, remain the gold standard for diagnosis; however, these methods are not reliable for early detection. Delayed diagnosis of a nonunion is costly from both the patient and treatment standpoints. In response, repeated efforts have been made to identify bone metabolic markers as diagnostic or prognostic tools for monitoring bone healing. Thus far, the evidence regarding a correlation between the kinetics of most bone metabolic markers and nonunion is very limited. With the aim of classifying the role of biological pathways of bone metabolism and of understanding bone conditions in the development of osteoporosis, advances have been made in our knowledge of the molecular basis of bone remodeling, fracture healing, and its failure. Procollagen type I amino-terminal propeptide has been shown to be a reliable bone formation marker in osteoporosis therapy and its kinetics during fracture healing has been recently described. In this article, we suggest that procollagen type I amino-terminal propeptide presents a good opportunity for early detection of nonunion. We also review the role and potential of serum PINP, as well as other markers, as indications of fracture healing.
-
Gamulin O., Serec K., Bilić V., Balarin M., Kosović M., Drmić D., Brčić L., Seiwerth S., Sikirić P., Monitoring the healing process of rat bones using Raman spectroscopy, Journal of Molecular Structure, 1044, 2013. Crossref
-
Campos Juliana Medeiros de, Prati Alexandre Javaroni, Cirano Fabiano Ribeiro, Pimentel Suzana Peres, Pastore Gabriel Pires, Pecorari Vanessa Gallego, Ribeiro Fernanda Vieira, Casati Marcio Zaffalon, Casarin Renato Corrêa Viana, Smoking Modulates Gene Expression of Type I Collagen, Bone Sialoprotein, and Osteocalcin in Human Alveolar Bone, Journal of Oral and Maxillofacial Surgery, 73, 11, 2015. Crossref
-
Guo Xiao Qin, Qi Lin, Yang Jing, Wang Yue, Wang Chuan, Li Zong Min, Li Ling, Qu Ye, Wang Dan, Han Ze Min, Salidroside accelerates fracture healing through cell-autonomous and non-autonomous effects on osteoblasts, Cell and Tissue Research, 367, 2, 2017. Crossref
-
Burgers Travis A, Vivanco Juan F, Zahatnansky Juraj, Moren Andrew J Vander, Mason James J, Williams Bart O, Mice with a heterozygous Lrp6 deletion have impaired fracture healing, Bone Research, 4, 1, 2016. Crossref
-
Kuo Yi-Jie, Sun Jui-Sheng, Rau Gary, Chen Chia-Hsien, Tsai Tung-Hu, Tsuang Yang-Hwei, Better Osteoporotic Fracture Healing with Sintered Dicalcium Pyrophosphate (SDCP) Treatment, Journal of Histochemistry & Cytochemistry, 62, 8, 2014. Crossref
-
Xiaofeng Li, Daxia Xu, Yunzhen Chen, Teriparatide as a nonoperative treatment for tibial and femoral fracture nonunion, Medicine, 96, 16, 2017. Crossref
-
Kumar Malhar, Shelke Dnyaneshwar, Shah Saumil, Prognostic potential of markers of bone turnover in delayed-healing tibial diaphyseal fractures, European Journal of Trauma and Emergency Surgery, 45, 1, 2019. Crossref
-
Burgers Travis A., Hoffmann Martin F., Collins Caitlyn J., Zahatnansky Juraj, Alvarado Martin A., Morris Michael R., Sietsema Debra L., Mason James J., Jones Clifford B., Ploeg Heidi L., Williams Bart O., Malaval Luc, Mice Lacking Pten in Osteoblasts Have Improved Intramembranous and Late Endochondral Fracture Healing, PLoS ONE, 8, 5, 2013. Crossref
-
Granchi Donatella, Gómez-Barrena Enrique, Rojewski Markus, Rosset Philippe, Layrolle Pierre, Spazzoli Benedetta, Donati Davide Maria, Ciapetti Gabriela, Changes of Bone Turnover Markers in Long Bone Nonunions Treated with a Regenerative Approach, Stem Cells International, 2017, 2017. Crossref
-
Sousa Cristina P., Dias Isabel R., Lopez-peña Mónica, Camassa José A., Lourenço Paulo J., Judas Fernando M., Gomes Manuela E., Reis Rui L., Bone turnover markers for early detection of fracture healing disturbances: A review of the scientific literature, Anais da Academia Brasileira de Ciências, 87, 2, 2015. Crossref
-
CAMASSA JOSÉ A., DIOGO CAMILA C., SOUSA CRISTINA P., AZEVEDO JORGE T., VIEGAS CARLOS A., REIS RUI L., DOURADO NUNO, DIAS ISABEL R., Bone turnover markers in sheep and goat: A review of the scientific literature, Anais da Academia Brasileira de Ciências, 89, 1, 2017. Crossref
-
Sousa Cristina P., Lopez-Peña Mónica, Guzón Fernando M., Abreu Humberto V. De, Luís Maurino R., Viegas Carlos A., Camassa José, Azevedo Jorge T. De, Cabrita António S., Reis Rui L., Gomes Manuela E., Dias Isabel R., Evaluation of bone turnover markers and serum minerals variations for predicting fracture healing versus non-union processes in adult sheep as a model for orthopedic research, Injury, 48, 8, 2017. Crossref
-
Yoon Byung-Ho, Yu Woojin, Clinical Utility of Biochemical Marker of Bone Turnover: Fracture Risk Prediction and Bone Healing, Journal of Bone Metabolism, 25, 2, 2018. Crossref
-
Granchi DONATELLA, CIAPETTI GABRIELA, GÓMEZ-BARRENA ENRIQUE, ROJEWSKI MARKUS, ROSSET PHILIPPE, LAYROLLE PIERRE, SPAZZOLI BENEDETTA, DONATI DAVIDE MARIA, BALDINI NICOLA, Biomarkers of bone healing induced by a regenerative approach based on expanded bone marrow–derived mesenchymal stromal cells, Cytotherapy, 21, 8, 2019. Crossref
-
Roberts Joseph L., Liu Guanglu, Darby Trevor M., Fernandes Lorenzo M., Diaz-Hernandez Martha E., Jones Rheinallt M., Drissi Hicham, Bifidobacterium adolescentis supplementation attenuates fracture-induced systemic sequelae, Biomedicine & Pharmacotherapy, 132, 2020. Crossref
-
Schwartz Elliott N., Edmondson Clinten P., Medical and Metabolic Considerations in Athletes With Stress Fractures, in Baxter's the Foot and Ankle in Sport, 2020. Crossref
-
Al-Sobayil Fahd, Sadan Madeh A., El-Shafaey El-Sayed, Ahmed Ahmed F., Can bone marrow aspirate improve mandibular fracture repair in camels (Camelus dromedarius)? A preliminary study, Journal of Veterinary Science, 21, 6, 2020. Crossref
-
Zou Zi, Liu Wei, Cao Lihua, Liu Ying, He Tiantian, Peng Shuping, Shuai Cijun, Advances in the occurrence and biotherapy of osteoporosis, Biochemical Society Transactions, 48, 4, 2020. Crossref
-
Albeshri Sultan, Alblaihess Abdulaziz, Niazy Abdurahman A, Ramalingam Sundar, Sundar Chalini, Alghamdi Hamdan S, Biomarkers as Independent Predictors of Bone Regeneration around Biomaterials: A Systematic Review of Literature, The Journal of Contemporary Dental Practice, 19, 5, 2018. Crossref
-
Crous Anine, Abrahamse Heidi, The Signalling Effects of Photobiomodulation on Osteoblast Proliferation, Maturation and Differentiation: A Review, Stem Cell Reviews and Reports, 17, 5, 2021. Crossref
-
Chitwood Joseph R., Chakraborty Nabarun, Hammamieh Rasha, Moe Sharon M., Chen Neal X., Kacena Melissa A., Natoli Roman M., Predicting fracture healing with blood biomarkers: the potential to assess patient risk of fracture nonunion, Biomarkers, 26, 8, 2021. Crossref
-
Magani Sri Krishna Jayadev, Mupparthi Sri Durgambica, Gollapalli Bhanu Prakash, Shukla Dhananjay, Tiwari AK, Gorantala Jyotsna, Yarla Nagendra Sastry, Tantravahi Srinivasan, Salidroside - Can it be a Multifunctional Drug?, Current Drug Metabolism, 21, 7, 2020. Crossref
-
Yu Lei, Li Wenming, Yang Peng, Zhang Wei, Tao Huaqiang, Ge Gaoran, Yang Huilin, Bai Jiaxiang, Wang Huaiyu, Geng Dechun, Osteoblastic microRNAs in skeletal diseases: Biological functions and therapeutic implications, Engineered Regeneration, 3, 3, 2022. Crossref
-
Trincă Lucia Carmen, Mareci Daniel, Souto Ricardo Manuel, Lozano-Gorrín Antonio Diego, Izquierdo Javier, Burtan Liviu, Motrescu Iuliana, Vulpe Vasile, Pavel Geta, Strungaru Stefan, Stoleriu Iulian, Strat Aurel Lulu, Solcan Carmen, Osseointegration evaluation of ZrTi alloys with hydroxyapatite-zirconia-silver layer in pig's tibiae, Applied Surface Science, 487, 2019. Crossref