Critical Reviews™ in Eukaryotic Gene Expression

ISSN for PRINT: 1045-4403

For Online Access

Best Paper Award Selection - Editorial Board Site

2002, Volume12

Issue 1

88 pages

DOI: 10.1615/CritRevEukaryotGeneExpr.v12.i1

Issue price - $169.00

Gilles B. Tremblay
Drug Discovery Unit, SignalGene Inc., Montreal, PQ H2M 2N9, Canada

Vincent Giguere
Molecular Oncology Group, McGill University Health Center, Montreal, PQ H3A 1A1, Canada

The estrogen receptors are members of a large family of transcription factors, which include receptors for steroid hormones, retinoids, vitamin D and thyroid hormone, as well as several orphan receptors with yet undiscovered ligands. The process by which small lipophilic molecules signal in target tissues is complex and involves nuclear receptor associations with a multitude of coregulator proteins. These proteins participate in and recruit many enzymatic and structural activities that allow modulation of chromatin structure to facilitate stimulation or repression of gene expression. This review will present an overview of those regulatory factors that interact with the estrogen receptors and participate in the transmission of the estrogenic signal.

DOI: 10.1615/CritRevEukaryotGeneExpr.v12.i1.10 Download article, 22 pages

Article price - $35.00

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