Critical Reviews™ in Eukaryotic Gene Expression

ISSN for PRINT: 1045-4403

For Online Access

Best Paper Award Selection - Editorial Board Site

2005, Volume15

Issue 3

98 pages

Issue price - $169.00

Motomi Osato
Institute of Molecular and Cell Biology, Oncology Research Institute, National University of Singapore, 138673 Singapore

Yoshiaki Ito
Oncology Research Institute, Blk MD 11, Clinical Research Centre, National University of Singapore, 10 Medical Drive, Level 5, Singapore 117597

RUNX1/AML1, located on chromosome 21, is a key factor in the generation and maintenance of hematopoietic stem cells and the gene most frequently implicated in human leukemias. Chromosome translocations and point mutations are well-documented genetic alterations in RUNX leukemia (also known as CBF leukemia). In addition, overdosage or overexpression of RUNX1 is suspected to be a third mode of RUNX1 involvement in leukemogenesis. The possibility that this mode might underlie Down syndrome-related leukemias caused by trisomy of chromosome 21 is discussed.

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