International Journal of Medicinal Mushrooms

ISSN for PRINT: 1521-9437

For Online Access

Best Paper Award Selection - Editorial Board Site

2006, Volume8

Issue 1

98 pages

DOI: 10.1615/IntJMedMushr.v8.i1

Issue price - $138.00

Tzi Bun Ng
Department of Biochemistry, Faculty of Medicine, The Chinese University of Hong Kong, Shatin, New Territories, Hong Kong, China

Hexiang Wang
Department of Biochemistry, The Chinese University of Hong Kong, Shatin, New Territories, Hong Kong, China

D. C. C. Wan
Department of Biochemistry, The Chinese University of Hong Kong, Shatin, New Territories, Hong Kong, China

Polysaccharopeptide from the Turkey Tail fungus Trametes (=Coriolus) versicolor has been reported to possess a number of important attributes including anticancer, immunomodulatory, analgesic, and hepatoprotective activities. In this investigation, it is shown that the polysaccharopeptide is capable of inhibiting human immunodeficiency virus type 1 (HIV-1) reverse transcriptase and protease, the two enzymes of paramount importance to the life cycle of the HIV. The polysaccharopeptide inhibits other proteases including trypsin, α-chymotrypsin, proteinase K, subtilisin, and elastase to a smaller extent. The anti-HIV enzyme and immunostimulatory activities of the mushroom polysaccharopeptide make it a potential candidate for the therapy of AIDS.

DOI: 10.1615/IntJMedMushr.v8.i1.40 Download article, 39-43 pages

Article price - $35.00

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