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International Journal of Medicinal Mushrooms

 

ISSN for PRINT: 1521-9437

Institutional price:

$538.00

Issues per year:

4

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Best Paper Award Selection - Editorial Board Site

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2006, Volume8

Issue 1

  98 pages  

DOI: 10.1615/IntJMedMushr.v8.i1   

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  • Moderate Angiotensin I Converting Enzyme (ACE) Inhibitors from the Edible Mushroom Pleurotus citrinopileatus Singer (Agaricomycetideae)
  • Hiroyuki Suzuki
    Laboratory of Bioresource Science, Department of Applied and Environmental Chemistry, Kitami Institute of Technology, Kitami 090-8507, Japan

    Masaaki Kiyoto
    Laboratory of Bioresource Science, Department of Applied and Environmental Chemistry, Kitami Institute of Technology, Kitami 090-8507, Japan

    Naoki Nobuyama
    Laboratory of Bioresource Science, Department of Applied and Environmental Chemistry, Kitami Institute of Technology, Kitami 090-8507, Japan

    Takaaki Hara
    Hakuju Life Science Co., Ltd., 32-17 Oyamahigashi-cho, Itabashi-ku, Tokyo 173-0004, Japan

    Yuzo Yagi
    Hakuju Life Science Co., Ltd., 32-17 Oyamahigashi-cho, Itabashi-ku, Tokyo 173-0004, Japan

    Iwao Togashi
    Department of Material Chemistry, Asahikawa National College of Technology, Asahikawa 071-8142, Japan

    Akira Harada
    Chemical Biology Institute, Inc., 4-9-2-1Utsukushigaoka, Kiyota-ku, Sapporo 004-0814, Japan

    Masakazu Aoyama
    Laboratory of Bioresource Science, Department of Applied and Environmental Chemistry, Kitami Institute of Technology, Kitami 090-8507, Japan


    ABSTRACT

    The acetone extract of Pleurotus citrinopileatus showed a moderate inhibitory activity against the angiotensin I converting enzyme (ACE). The 50% inhibitory concentration (IC50) of the extract for ACE activity was 50.2 mg ml−1. D-mannitol was isolated as an active principle with a yield of 5.75 %. The IC50 value of the compound was 33.4 mg ml−1. D-arabitol and glycerol were also detected in the acetone extract. D-arabitol acted as an ACE inhibitor, whereas only limited activity was observed by the dose of glycerol.

    DOI: 10.1615/IntJMedMushr.v8.i1.50

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